nm23基因表达与乳腺癌远处转移及预后相关性的研究

被引：28

作者：

刘红

毛慧生

傅西林

方志沂

冯玉梅

范宇

李树玲

机构：

[1] 天津医科大学附属肿瘤医院乳腺科,天津医科大学附属肿瘤医院肿瘤研究所,天津医科大学附属肿瘤医院肿瘤研究所,天津医科大学附属肿瘤医院乳腺科,天津医科大学附属肿瘤医院肿瘤研究所,天津医科大学附属肿瘤医院肿瘤研究所,天津医科大学附属肿瘤医院乳腺科

来源：

中华肿瘤杂志 | 2001年 / 03期

关键词：

nm23基因; 乳腺肿瘤; 肿瘤转移; 预后; 免疫组织化学; 聚合酶链反应;

D O I：

暂无

中图分类号：

R737.9 [乳腺肿瘤];

学科分类号：

摘要：

目的　探讨nm2 3基因表达与乳腺癌远处转移的关系及其预后意义。方法　选取两组共 16 9例乳腺癌患者 ,应用免疫组化和RT PCR方法检测nm2 3基因表达。结果　nm2 3基因表达与乳腺癌远处转移及腋淋巴结转移呈显著负相关 ,与生存率呈正相关。第 1组病例发生远处转移的 9例腋淋巴结阴性患者中 ,7例为nm2 3蛋白低表达 ;而 2 9例未发生远处转移的腋淋巴结阳性患者中 ,nm2 3蛋白中表达及高表达者为 2 4例 (82 .8% )。第 2组发生复发和远处转移的 6例患者其nm2 3mRNA均低表达。nm2 3基因表达与腋淋巴结转移、肿瘤大小均为影响预后的因素。结论　nm2 3基因作为一个独立的预后指标应用 ,可弥补常规指标的不足 ,具有重要的临床应用价值。

引用

页码：48 / 51

页数：4

共 8 条

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