他汀类药物的临床试验研究进展

被引：1

作者：

石卫晨

兰永乔

刘彬

机构：

[1] 成都市第七人民医院

来源：

现代临床医学 | 2012年 / 38卷 / 02期

关键词：

他汀类; 降脂治疗; 血管镜; 血管内超声; 低密度脂蛋白; LDL; 药物治疗; 斑块体积; 临床试验; 研究进展;

D O I：

暂无

中图分类号：

R96 [药理学];

学科分类号：

100602 ; 100706 ;

摘要：

<正>他汀类药物降脂治疗的作用是减少胆固醇(C)在肝脏的合成,并通过竞争性抑制羟甲基戊二酰辅酶A还原酶的活性来表达的。细胞内胆固醇浓度的下降导致肝细胞表面低密度脂蛋白(LDL)受体的表达,其结果是增加了低密度脂蛋白胆固醇(LDL-C)从血液中的排除,减少了血循环中LDL-C的浓度,和其他血脂包括富含甘油三酯(TG)颗粒的载脂蛋白B的下降。最新的指南[1]与以前相比更加强调心血管危险度决定降脂治疗的决择,取消"血脂合适范围"描述;干预靶点:

引用

页码：147 / 149+158 +158-159

页数：5

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