骨软骨组织界面结构及骨软骨复合组织构建研究

被引：11

作者：

段小军

王富友

杨柳

机构：

[1] 第三军医大学西南医院关节外科

来源：

中国矫形外科杂志 | 2013年 / 21卷 / 17期

关键词：

骨软骨复合组织; 界面结构; 缺损;

D O I：

暂无

中图分类号：

R318.08 [生物材料学];

学科分类号：

100103 [病原生物学];

摘要：

<正>关节部位骨软骨复合组织缺损在医学临床十分常见,可由外伤、退变、手术切除(如肿瘤)、感染和结缔组织疾病等引起,表现为顽固性疼痛、关节活动受限,目前已成为肢体残障的主要原因之一[1-2]。据统计美国目前骨软骨缺损的发病率约为0.15%～0.3%,其中每年用于治疗含骨软骨缺损的骨性关节炎的直接医疗费用就高达286亿美元,随着全民健身运动普及和社会老龄化等因素,其发病率以每年7.3%的速度递增[3]。由于软骨组织缺乏血供,再生修复能力非常差,目前主要治疗方法均有明显缺陷[4],这也促进了骨软骨复合组织的基础研究和临床应用研究不断深入,而骨软骨组织界面结构研究是其中的难点和重点,现就其研究进展进行综述。

引用

页码：1729 / 1733

页数：5

共 16 条

[1]

Scaffold-Based Repair for Cartilage Healing: A Systematic Review and Technical Note [J].

Filardo, Giuseppe ;

Kon, Elizaveta ;

Roffi, Alice ;

Di Martino, Alessandro ;

Marcacci, Maurilio .

ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY, 2013, 29 (01) :174-186

[2]

Engineering osteochondral constructs through spatial regulation of endochondral ossification.[J].Eamon J. Sheehy;Tatiana Vinardell;Conor T. Buckley;Daniel J. Kelly.Acta Biomaterialia.2012,

[3]

Extracellular matrix scaffolds for cartilage and bone regeneration.[J]..Trends in Biotechnology.2012,

[4]

Repair of articular cartilage defects with tissue-engineered osteochondral composites in pigs.[J].Weiding Cui;Qing Wang;Gang Chen;Shixiang Zhou;Qing Chang;Qiang Zuo;Kewei Ren;Weimin Fan.Journal of Bioscience and Bioengineering.2010, 4

[5]

Regeneration of the articular surface of the rabbit synovial joint by cell homing: a proof of concept study [J].

Lee, Chang H. ;

Cook, James L. ;

Mendelson, Avital ;

Moioli, Eduardo K. ;

Yao, Hai ;

Mao, Jeremy J. .

LANCET, 2010, 376 (9739) :440-448

[6]

Bioactive Stratified Polymer Ceramic-Hydrogel Scaffold for Integrative Osteochondral Repair [J].

Jiang, Jie ;

Tang, Amy ;

Ateshian, Gerard A. ;

Guo, X. Edward ;

Hung, Clark T. ;

Lu, Helen H. .

ANNALS OF BIOMEDICAL ENGINEERING, 2010, 38 (06) :2183-2196

[7]

The subchondral bone: a new frontier in articular cartilage repair [J].

Madry, Henning .

KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY, 2010, 18 (04) :417-418

[8]

The subchondral bone in articular cartilage repair: current problems in the surgical management [J].

Gomoll, Andreas H. ;

Madry, Henning ;

Knutsen, Gunnar ;

van Dijk, Niek ;

Seil, Romain ;

Brittberg, Mats ;

Kon, Elizaveta .

KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY, 2010, 18 (04) :434-447

[9]

Histomorphometric analysis of adult articular calcified cartilage zone [J].

Wang, Fuyou ;

Ying, Zhang ;

Duan, Xiaojun ;

Tan, Hongbo ;

Yang, Bin ;

Guo, Lin ;

Chen, Guangxing ;

Dai, Gang ;

Ma, Zhe ;

Yang, Liu .

JOURNAL OF STRUCTURAL BIOLOGY, 2009, 168 (03) :359-365

[10]

Tissue engineering of cartilage using an injectable and adhesive chitosan-based cell-delivery vehicle.[J].C.D. Hoemann;J. Sun;A. Légaré;M.D. McKee;M.D. Buschmann.Osteoarthritis and Cartilage.2004, 4

← 1 2 →