DNA甲基化修饰在乙肝病毒持续感染相关肝病中的研究现状

被引：10

作者：

凌青霞

陈明泉

施光峰

机构：

[1] 复旦大学附属华山医院

来源：

肝脏 | 2014年 / 19卷 / 05期

关键词：

D O I：

10.14000/j.cnki.issn.1008-1704.2014.05.010

中图分类号：

R512.62 [];

学科分类号：

摘要：

<正>乙型肝炎病毒(Hepatitis B virus,HBV)为双链DNA嗜肝病毒,其感染在世界范围内流行。目前全球约有近4亿HBV慢性感染者,其中我国约占一亿。而每年更有近100万人死于HBV感染所致的肝衰竭、肝硬化及原发性肝癌[1]。但迄今为止,HBV感染慢性化、其持续感染所致的肝硬化及原发性肝癌的具体机制尚未明了,这也是改善HBV慢性感染相关疾病高死亡率的主要难点。1939年,英国科学家Waddington CH首次提出了表观遗

引用

页码：362 / 364

页数：3

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