急性肾损伤生物标志物在危重症患者中的研究进展

被引：4

作者：

罗仁杰 ^{[1
]}

杜晓刚 ^{[2
]}

陈雪梅 ^{[1
]}

机构：

[1] 重庆医科大学附属第一医院急诊科

[2] 重庆医科大学附属第一医院肾内科

来源：

重庆医科大学学报 | 2020年 / 45卷 / 05期

关键词：

急性肾损伤; 生物标志物; 重症监护室; 危重症患者;

D O I：

10.13406/j.cnki.cyxb.002369

中图分类号：

R692 [肾疾病]; R459.7 [急症、急救处理];

学科分类号：

100218 ;

摘要：

急性肾损伤(acute kidney injury,AKI)是重症监护室(intensive care units,ICU)患者的常见疾病,死亡率高。目前,改善全球肾脏病预后组织(Kidney Disease:Improving Global Outcomes,KDIGO)发布的最新AKI临床实践指南仍以血肌酐值及尿量作为AKI的诊断标准,对AKI的早期发现存在一定局限性。近年来,一些AKI生物标志物已经在临床实践中得到验证,如中性粒细胞明胶酶相关脂质运载蛋白、白介素-18、肾损伤分子-1、L型脂肪酸结合蛋白、胰岛素样生长因子结合蛋白-7和组织抑制金属蛋白酶-2、MicroRNA(miRNA)等,但因ICU中AKI患者存在更复杂的发病机制和病理生理学改变,这些生物标志物在ICU中并没有得到广泛使用,本文就AKI的新型生物标志物在ICU患者中的研究进展作一综述。

引用

页码：561 / 565

页数：5

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