外泌体标志物和肿瘤液体活检的研究进展及现状

被引：10

作者：

林宇晟 ^{[1
,2
,3
]}

甘进锋 ^{[1
]}

江钰琛 ^{[1
]}

王飞寒 ^{[1
]}

张灏 ^{[1
]}

机构：

[1] 暨南大学医学院肿瘤精准医学研究所

[2] 汕头大学医学院肿瘤研究中心

[3] 荷兰格罗宁根大学医学中心血液科

来源：

中国癌症防治杂志 | 2019年 / 11卷 / 02期

关键词：

外泌体; 液体活检; 标志物; 肿瘤;

D O I：

暂无

中图分类号：

R730.4 [肿瘤诊断学];

学科分类号：

100214 [肿瘤学];

摘要：

外泌体是内体循环途径的最终产物,主要来源于细胞内溶酶体微粒内陷形成的晚期核内体,经核内体外膜与细胞膜融合后释放到胞外基质中,与其他类型的细胞外囊泡不同。疾病来源的外泌体在全身的体液中都可检测到,且其内含有来源细胞的所有分子谱,因此外泌体成为液体活检中的后起之秀。外泌体是细胞间交换物质、传递信息的重要信使。外泌体介导的细胞间信息交流,既可影响正常的生理过程,在包括肿瘤在内的多种疾病发生发展中也发挥关键作用。本文概述了多种外泌体生物标志物的最新研究进展,尤其是在恶性肿瘤诊断、肿瘤发展监控、监测治疗反应和评估预后中的应用。

引用

页码：99 / 103

页数：5

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