酪氨酸蛋白激酶与突触可塑性及学习记忆的关系

被引:3
作者
李昕
宫泽辉
刘克良
机构
[1] 军事医学科学院毒物药物研究所
[2] 军事医学科学院毒物药物研究所 北京
[3] 北京
关键词
酪氨酸蛋白激酶; 可塑性; 记忆; Trk受体; Src家族; Eph受体;
D O I
暂无
中图分类号
R338 [神经生理学];
学科分类号
0710 ; 071006 ;
摘要
近年来酪氨酸磷酸化在成年哺乳动物神经系统中的重要作用逐渐受到重视,酪氨酸蛋白激酶在调控与细胞增殖、分化、迁移及代谢相关的信号转导通路中起关键作用。本文主要对三种不同的酪氨酸蛋白激酶信号级联过程,即Trk受体酪氨酸激酶级联,Src家族非受体酪氨酸激酶级联及Eph受体酪氨酸激酶级联,以及它们在成年动物神经元突触可塑性及学习记忆形成过程中的重要作用及可能机制作一综述。
引用
收藏
页码:141 / 144
页数:4
相关论文
共 24 条
[1]  
G-protein-coupled receptors act via protein kinase C and Src to regulate NMDA receptors. Lu WY,Xiong ZG,Lei S et al. National Neuroscience . 1999
[2]  
Regulation of synaptic responses to highfrequency stimulation and LTP by neurotrophins in the hippocampus. Figurov A,Pozzo-Miller LD,Olafsson P et al. Nature . 1996
[3]  
Neuron[P]. KUTKOVETSKYI VALENTYN YAKOVYCH;TURTI MARYNA VALENTYNIVNA.UA106289U,2016-04-25
[4]  
Trk receptors: mediators of neurotrophin action. Patapoutian A,Reichardt LF. Current Opinion in Neurobiology . 2001
[5]  
Transgenic mice overexpressing truncated trkB neurotrophin receptors in neurons have impaired long-term spatial memory but normal hippocampal LTP. Saarelainen T,Pussinen R,Koponen E et al. Synapse . 2000
[6]  
Trans-synaptic Eph receptor-ephrin signaling in hippocampal mossy fiber LTP. Contractor A,Rogers C,Maron C et al. Science . 2002
[7]  
Neuron[P]. KUTKOVETSKYI VALENTYN YAKOVYCH;TURTI MARYNA VALENTYNIVNA.UA106289U,2016-04-25
[8]  
Anesthesia induced retrograde amnesia is ameliorated by ephrinA5 -IgG in mice: EphA receptor tyrosine kinases are involved in mammalian memory. Gerlai R,McNamara A. Behavioural Brain Research . 2000
[9]  
Impaired long-term potentiation, spatial learning and hippocampal development in fyn mutant mice. Grant SG,O’ Dell TJ,Karl KA et al. Science . 1992
[10]  
Deprivation of endogenous brain-derived neurotrophic factor results in impairment of spatial learning and memory in adult rats. Mu JS,Li WP,Yao ZB et al. Brain Research . 1999