超高效液相色谱-串联质谱法测定酒、牡蛎粉、咖啡中2种那非类物质的含量

被引：2

作者：

金绍明

高文超

宁霄

曹进

丁宏

机构：

[1] 中国食品药品检定研究院

来源：

食品安全质量检测学报 | 2017年 / 8卷 / 07期

关键词：

超高效液相色谱-串联质谱法; 去甲基他达拉非; 硫代西地那非; 食品;

D O I：

暂无

中图分类号：

O657.63 [质谱分析]; TS207.3 [食品分析与检验];

学科分类号：

摘要：

目的建立超高效液相色谱-串联质谱法(ultra performance liquid chromatography-tandem mass spectrometry,UPLC-MS/MS)测定酒、牡蛎粉、咖啡中那非类物质含量的分析方法。方法采用Waters HSS T3(2.1 mm×100 mm,1.8μm)反相色谱柱,以0.1%甲酸水和0.1%甲酸乙腈为流动相进行梯度洗脱,经质谱多反应监测(multiple reaction monitor,MRM)法进行检测。结果在10～200 ng/mL的浓度范围内,去甲基他达拉非和硫代西地那非均表现出良好的线性关系,2种化合物的检出限分别为50 ng/g和50 ng/mL,定量限分别为100 ng/g和100 ng/mL。结论该方法操作简便,结果可靠,灵敏度高,可用于食品中去甲基他达拉非和硫代西地那非含量的快速测定。

引用

页码：2448 / 2452

页数：5

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