大肠癌及腺瘤中caspase-3和bcl-2的表达及临床意义

被引：8

作者：

吴运生

程清洲

机构：

[1] 武汉工业学院医学院

[2] 武汉工业学院医学院武汉

[3] 武汉

来源：

数理医药学杂志 | 2003年 / 04期

关键词：

大肠癌; bcl-2; caspase-3; 免疫组织化学;

D O I：

暂无

中图分类号：

R735.34 [];

学科分类号：

100214 ;

摘要：

为探讨大肠腺瘤和大肠癌中 bcl-2和 caspase-3基因的蛋白表达及其与临床病理指标的可能关系 ,采用免疫组织化学 S-P方法检测 15例正常大肠粘膜、3 9例大肠腺瘤和 62例大肠腺癌标本中 bcl-2和 caspase-3的表达。结果显示 ,在正常大肠粘膜、腺瘤和腺癌中bcl-2和 caspase-3的阳性表达率分别为 2 6.7% ( 4 /15 )、86.7% ( 13 /15 ) ,5 9.0 % ( 2 3 /3 9)、5 6.4% ( 2 2 /3 9) ,77.4% ( 4 8/62 )、45 .2 % ( 2 8/62 ) ;腺瘤和腺癌分别与正常大肠粘膜比较 bcl-2和 caspase-3的表达差异均有显著性 ( P<0 .0 5 ) ;bcl-2和 caspase-3的蛋白表达均与大肠癌组织学类型、淋巴结转移和 Dukes分期无明显相关 ,而与组织学分级和术后 5年生存率有明显相关性 ( P<0 .0 5 )

引用

页码：300 / 302

页数：3

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