In-vitro cytotoxic activity of β-Sitosterol triacontenate isolated from Capparis decidua(Forsk.) Edgew

被引：5

作者：

Permender Rathee ^{[1
]}

Dharmender Rathee ^{[2
]}

Deepti Rathee ^{[2
]}

Sushila Rathee ^{[1
]}

机构：

[1] Department of Quality Assurance & Natural Products,PDM College of Pharmacy,Bahadurgarh,India

[2] Department of Natural Products,JCDM College of Pharmacy,Sirsa,India

来源：

Asian Pacific Journal of Tropical Medicine | 2012年 / 03期

关键词：

Kair; Capparis decidua; Capparidaceae; β-Sitosterol triacontenate; Anticancer activity;

D O I：

暂无

中图分类号：

R284 [中药化学];

学科分类号：

1008 ;

摘要：

Objective:To study the isolation and characterization of the constituent responsible for the cytotoxic activity of the ethanolic extract of stem of Capparis decidua(C.decidua).Methods:The preliminary cytotoxic effect of isolated compound(β-Sitosterol triacontenate) was investigated by MTT assay on A549 solid tumor cells.Results:IC50value of theβ-Sitosterol triacontenate was found to be 1μM.The cytotoxic activity increased in a dose dependent manner in case ofβ-Sitosterol triacontenate.Conclusions:The data therefore provide direct evidence for the role ofβ-Sitosterol triacontenate as a potent antimetastatic agent,which can markedly inhibit the metastatic and invasive capacity of malignant cells.

引用

页码：225 / 230

页数：6

共 3 条

[1]

Goyal, Rajni,Grewal, Rajbala.Hypocholesterolemic effect of teent (Capparis decidua) in hyperlipidemic obese adults[J].Nutrition and Food Science,2010

[2] Sedative and anticonvulsant effects of an alcoholic extract of Capparis decidua [J].

Goyal, Manoj ;

Nagori, B. P. ;

Sasmal, D. .

JOURNAL OF NATURAL MEDICINES, 2009, 63 (04) :375-379

[3]

Ashok Purohit,K.B. Vyas.Antiatherosclerotic Effect of Caparis decidua . Fruit Extract in Cholesterol-fed Rabbits[J].Pharmaceutical Biology,2006(3)

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