红景天苷对戊巴比妥钠所致小鼠睡眠时间影响的实验研究

被引:6
作者
李尔逊
许光辉
李廷利
郭冷秋
黄莉莉
机构
[1] 黑龙江中医药大学中药药理教研室
关键词
红景天苷; 镇静; 催眠;
D O I
10.19664/j.cnki.1002-2392.2008.01.009
中图分类号
R285.5 [中药实验药理];
学科分类号
摘要
目的:观察红景天苷对戊巴比妥钠致小鼠睡眠时间的影响。方法:本实验采用延长戊巴比妥钠所致小鼠睡眠时间的实验,研究红景天苷镇静催眠的药理作用。翻正反射消失即睡眠开始,实验指标为睡眠潜伏期和睡眠持续时间。结果:红景天苷能明显缩短戊巴比妥钠(55mg/kg,i.p.)所致小鼠睡眠的睡眠潜伏期和显著延长睡眠持续时间。结论:红景天苷具有明显的镇静催眠作用,且量效关系显著。
引用
收藏
页码:25 / 26
页数:2
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[1]  
Tetrandrine, a bisbenzylisoquinoline alkaloid from Chinese herb Radix, augmented the hypnotic effect of pentobarbital through serotonergic system[J] . Xin Zhao,Xiang-Yu Cui,Bao-Qiong Chen,Qing-Ping Chu,Hai-Yan Yao,Bao-Shan Ku,Yong-He Zhang.European Journal of Pharmacology . 2004 (2)
[2]  
Antidepressant, anxiogenic, and antinociceptive properties of levofloxacin in rats and mice[J] . B.F Erden,G Ulak,F Yildiz,T Utkan,S Ozdemirci,N Gacar.Pharmacology, Biochemistry and Behavior . 2001 (3)
[3]  
Preparative isolation and purification of salidroside from the Chinese medicinal plant Rhodiola sachalinensis by high-speed counter-current chromatography[J] . Hua-Bin Li,Feng Chen.Journal of Chromatography A . 2001 (1)
[4]  
Neurosteroidal modulation of social isolation-induced decrease in pentobarbital sleep in mice[J] . Kinzo Matsumoto,Kazuma Ojima,Hiroshi Watanabe.Brain Research . 1996 (1)