A Review on the Crosstalk between Insulin and Wnt/β-Catenin Signalling for Bone Health

被引：16

作者：

Wong, Sok Kuan ^{[1
]}

Mohamad, Nur Vaizura ^{[2
]}

Jayusman, Putri Ayu ^{[3
]}

Ibrahim, Nurul'Izzah ^{[1
]}

机构：

[1] Univ Kebangsaan Malaysia, Fac Med, Dept Pharmacol, Jalan Yaacob Latif,Bandar Tun Razak,Cheras, Kuala Lumpur 56000, Malaysia

[2] Univ Kebangsaan Malaysia, Fac Pharm, Ctr Drug & Herbal Dev, Jalan Raja Muda Abdul Aziz, Kuala Lumpur 50300, Malaysia

[3] Univ Kebangsaan Malaysia, Fac Dent, Dept Craniofacial Diagnost & Biosci, Jalan Raja Muda Abdul Aziz, Kuala Lumpur 50300, Malaysia

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2023年 / 24卷 / 15期

关键词：

bone loss; glycogen synthase kinase-3 beta; GSK3; beta; type 1 diabetes mellitus; type 2 diabetes mellitus; GROWTH-FACTOR-I; ESTROGEN-RECEPTOR; SERUM SCLEROSTIN; MINERAL DENSITY; WNT; OSTEOBLASTS; SENSITIVITY; METABOLISM; ACTIVATION; EXPRESSION;

D O I：

10.3390/ijms241512441

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

A positive association between insulin resistance and osteoporosis has been widely established. However, crosstalk between the signalling molecules in insulin and Wingless (Wnt)/beta-(beta-)catenin transduction cascades orchestrating bone homeostasis remains not well understood. The current review aims to collate the existing evidence, reporting (a) the expression of insulin signalling molecules involved in bone-related disorders and (b) the expression of Wnt/beta-catenin signalling molecules involved in governing insulin homeostasis. The downstream effector molecule, glycogen synthase kinase-3 beta (GSK3 beta), has been identified to be a point of convergence linking the two signal transduction networks. This review highlights that GSK3 beta may be a drug target in the development of novel anabolic agents and the potential use of GSK3 beta inhibitors to treat bone-related disorders.

引用

页数：20

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