A Mechanically Reinforced Super Bone Glue Makes a Leap in Hard Tissue Strong Adhesion and Augmented Bone Regeneration

被引：39

作者：

Hu, Shanshan ^{[1
]}

Wang, Shan ^{[1
]}

He, Qingqing ^{[1
]}

Li, Dize ^{[1
]}

Xin, Liangjing ^{[1
]}

Xu, Chuanhang ^{[1
]}

Zhu, Xingyu ^{[1
]}

Mei, Li ^{[2
]}

Cannon, Richard D. ^{[2
]}

Ji, Ping ^{[1
]}

Tang, Han ^{[1
]}

Chen, Tao ^{[1
]}

机构：

[1] Chongqing Med Univ, Stomatol Hosp, Chongqing Key Lab Oral Dis & Biomed Sci, Chongqing Municipal Key Lab Oral Biomed Engn High, Chongqing 401147, Peoples R China

[2] Univ Otago, Sir John Walsh Res Inst, Fac Dent, Dept Oral Sci, Dunedin 9054, New Zealand

来源：

ADVANCED SCIENCE | 2023年 / 10卷 / 11期

基金：

中国国家自然科学基金; 中国博士后科学基金;

关键词：

bone fracture; L-dopa amino acid; mussel; osteogenesis; zeolitic imidazolate framework-8; MUSSEL PROTEIN; HYDROGEL; GRAFTS;

D O I：

10.1002/advs.202206450

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

Existing bone tissue engineering strategies aim to achieve minimize surgical trauma, stabilize the injured area, and establish a dynamic osteogenic microenvironment. The cutting-edge bone glue developed in this study satisfies these criteria. Inspired by the excellent adhesive properties of mussels, herein, a super osteogenic glue (L-DPZ) that integrates poly(vinyl alcohol), L-dopa amino acid, and zeolitic imidazolate framework-8 characterized by catechol-metal coordination is used to successfully adhere to hard tissue with a maximum adhesive strength of 10 MPa, which is much higher than those of commercial and previously reported bone glues. The stable hard tissue adhesion also enables it to adhere strongly to luxated or broken teeth, Bio-Oss (a typical bone graft material), and splice fragments from comminuted fractures of the rabbit femur. Then, it is testified that the L-DPZ hydrogels exhibit satisfactory biocompatibility, stable degradability, and osteogenic ability in vitro. Moreover, the ability to anchor Bio-Oss and sustained osteogenesis of L-DPZ result in satisfactory healing in calvarial bone defect models in rabbits, as observed by increased bone thickness and the ingrowth of new bone tissue. These results are expected to demonstrate solutions to clinical dilemmas such as comminuted bone fracture fixation, bone defect reconstruction, and teeth dislocation replantation.

引用

页数：15

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