An Updated Review of Hypertrophic Scarring

被引：93

作者：

Mony, Manjula P. ^{[1
]}

Harmon, Kelly A. ^{[1
]}

Hess, Ryan ^{[1
]}

Dorafshar, Amir H. ^{[1
]}

Shafikhani, Sasha H. ^{[2
,3
]}

机构：

[1] Rush Univ, Dept Surg, Div Plast & Reconstruct Surg, Med Ctr, Chicago, IL 60612 USA

[2] Rush Univ, Dept Med, Div Hematol & Oncol & Cell Therapy, Med Ctr, Chicago, IL 60612 USA

[3] Rush Univ, Canc Ctr, Med Ctr, Chicago, IL 60612 USA

来源：

CELLS | 2023年 / 12卷 / 05期

关键词：

normal (acute) wound healing; hypertrophic scar; keloids; animal models; treatments; FIBROBLAST-GROWTH-FACTOR; WOUND REPAIR; TRIAMCINOLONE ACETONIDE; TRAUMATIC SCARS; BASIC SCIENCE; RABBIT EAR; NUDE-MOUSE; TGF-BETA; SKIN; MODEL;

D O I：

10.3390/cells12050678

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Hypertrophic scarring (HTS) is an aberrant form of wound healing that is associated with excessive deposition of extracellular matrix and connective tissue at the site of injury. In this review article, we provide an overview of normal (acute) wound healing phases (hemostasis, inflammation, proliferation, and remodeling). We next discuss the dysregulated and/or impaired mechanisms in wound healing phases that are associated with HTS development. We next discuss the animal models of HTS and their limitations, and review the current and emerging treatments of HTS.

引用

页数：22

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