Molecular and Cellular Mechanisms of Osteoporosis

被引：84

作者：

Zhivodernikov, Ivan V. ^{[1
]}

Kirichenko, Tatiana V. ^{[1
]}

Markina, Yuliya V. ^{[1
]}

Postnov, Anton Y. ^{[1
]}

Markin, Alexander M. ^{[1
]}

机构：

[1] Petrovsky Natl Res Ctr Surg, Lab Cellular & Mol Pathol Cardiovasc Syst, Moscow 119991, Russia

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2023年 / 24卷 / 21期

关键词：

osteoporosis; inflammation; estrogen deficiency; bone resorption; DEFICIENCY-INDUCED OSTEOPOROSIS; INDUCED BONE LOSS; THYROID C-CELLS; PYRROLOQUINOLINE QUINONE; OSTEOGENIC DIFFERENTIATION; ESTROGEN-RECEPTOR; ANTI-OSTEOPOROSIS; OXIDATIVE STRESS; DNA METHYLATION; RAT MODEL;

D O I：

10.3390/ijms242115772

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Osteoporosis is a widespread systemic disease characterized by a decrease in bone mass and an imbalance of the microarchitecture of bone tissue. Experimental and clinical studies devoted to investigating the main pathogenetic mechanisms of osteoporosis revealed the important role of estrogen deficiency, inflammation, oxidative stress, cellular senescence, and epigenetic factors in the development of bone resorption due to osteoclastogenesis, and decreased mineralization of bone tissue and bone formation due to reduced function of osteoblasts caused by apoptosis and age-depended differentiation of osteoblast precursors into adipocytes. The current review was conducted to describe the basic mechanisms of the development of osteoporosis at molecular and cellular levels and to elucidate the most promising therapeutic strategies of pathogenetic therapy of osteoporosis based on articles cited in PubMed up to September 2023.

引用

页数：22

共 196 条

[1]

Sclerostin inhibition: A novel target for the treatment of postmenopausal osteoporosis [J].

Aditya, Suruchi ;

Rattan, Aditya .

JOURNAL OF MID-LIFE HEALTH, 2021, 12 (04) :267-275

[2]

Reactive Oxygen Species in Osteoclast Differentiation and Possible Pharmaceutical Targets of ROS-Mediated Osteoclast Diseases [J].

Agidigbi, Taiwo Samuel ;

Kim, Chaekyun .

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2019, 20 (14)

[3]

Understanding Osteoporosis: Human Bone Density, Genetic Mechanisms, Gut Microbiota, and Future Prospects [J].

Ahire, Jayesh J. ;

Kumar, Vikram ;

Rohilla, Alka .

PROBIOTICS AND ANTIMICROBIAL PROTEINS, 2024, 16 (03) :875-883

[4]

SIRT7 regulates lipogenesis in adipocytes through deacetylation of PPARγ2 [J].

Akter, Fatema ;

Tsuyama, Tomonori ;

Yoshizawa, Tatsuya ;

Sobuz, Shihab U. ;

Yamagata, Kazuya .

JOURNAL OF DIABETES INVESTIGATION, 2021, 12 (10) :1765-1774

[5]

Alto LT, 2017, METHODS MOL BIOL, V1493, P1, DOI 10.1007/978-1-4939-6448-2_1

[6]

Anupama D S, 2023, Sultan Qaboos Univ Med J, V23, P387, DOI [10.18295/squmj.1.2023.010, 10.18295/squmj.1.2023.010]

[7]

Exploring the regulatory mechanism of osteoporosis based on intestinal flora: A review [J].

Awuti, Kasimu ;

Wang, Xukai ;

Sha, Liquan ;

Leng, Xiangyang .

MEDICINE, 2022, 101 (52)

[8]

Molecular and spatial mechanisms governing STING signalling [J].

Balka, Katherine R. ;

De Nardo, Dominic .

FEBS JOURNAL, 2021, 288 (19) :5504-5529

[9]

Bandeira L, 2022, ARCH ENDOCRIN METAB, V66, P707

[10]

Melatonin and Related Compounds: Antioxidant and Anti-Inflammatory Actions [J].

Bantounou, Maria ;

Plascevic, Josip ;

Galley, Helen F. .

ANTIOXIDANTS, 2022, 11 (03)

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