The oncogenic roles and clinical implications of YAP/TAZ in breast cancer

被引：62

作者：

Luo, Juan ^{[1
]}

Zou, Hailin ^{[1
]}

Guo, Yibo ^{[1
]}

Tong, Tongyu ^{[1
,2
]}

Chen, Yun ^{[1
]}

Xiao, Yunjun ^{[1
]}

Pan, Yihang ^{[1
,3
]}

Li, Peng ^{[1
,3
]}

机构：

[1] Sun Yat Sen Univ, Affiliated Hosp 7, Sci Res Ctr, 628 Zhenyuan Rd, Shenzhen 518107, Guangdong, Peoples R China

[2] Sun Yat Sen Univ, Affiliated Hosp 7, Pelv Floor Disorders Ctr, Dept Urol, 628 Zhenyuan Rd, Shenzhen 518107, Guangdong, Peoples R China

[3] Sun Yat Sen Univ, Affiliated Hosp 7, Guangdong Prov Key Lab Digest Canc Res, 628 Zhenyuan Rd, Shenzhen 518107, Guangdong, Peoples R China

来源：

BRITISH JOURNAL OF CANCER | 2023年 / 128卷 / 09期

基金：

中国国家自然科学基金;

关键词：

HIPPO SIGNALING-PATHWAY; INVASIVE LOBULAR CARCINOMA; TEAD TRANSCRIPTION FACTORS; INTEGRIN-LINKED KINASE; CELL-PROLIFERATION; STEM-CELLS; CONTACT INHIBITION; SINGLE-AGENT; ORGAN SIZE; OPEN-LABEL;

D O I：

10.1038/s41416-023-02182-5

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Breast cancer (BC) is the most commonly diagnosed form of cancer and a leading cause of cancer-related deaths among women worldwide. Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ) are homologous transcriptional coactivators and downstream effectors of Hippo signalling. YAP/TAZ activation has been revealed to play essential roles in multiple events of BC development, including tumour initiation, progression, metastasis, drug resistance and stemness regulations. In this review, we will first give an overview of YAP/TAZ-mediated oncogenesis in BC, and then systematically summarise the oncogenic roles of YAP/TAZ in various BC subtypes, BC stem cells (BCSCs) and tumour microenvironments (TMEs). Based on these findings, we will further discuss the clinical implications of YAP/TAZ-based targeted therapies in BC and the potential future direction.

引用

页码：1611 / 1624

页数：14

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