Fospropofol assay: issues and impact on pharmacokinetic and pharmacodynamic evaluation

被引：8

作者：

Shah, Ajit ^{[1
]}

Mistry, Bipin ^{[2
]}

Gibiansky, Ekaterina ^{[2
,3
]}

Gibiansky, Leonid ^{[4
]}

机构：

[1] MGI PHARMA Inc, Eisai, Bloomington, MN 55437 USA

[2] MGI PHARMA Inc, Baltimore, MD USA

[3] ICON Dev Solut, Ellicott City, MD USA

[4] Metrum Res Grp Llc, Tariffville, CT USA

来源：

EUROPEAN JOURNAL OF ANAESTHESIOLOGY | 2009年 / 26卷 / 01期

关键词：

PROPOFOL PRODRUG GPI-15715; WATER-SOLUBLE PRODRUG; BOLUS INJECTION; VOLUNTEERS;

D O I：

10.1097/EJA.0b013e32831bc285

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

引用

收藏

页码：81 / 81

页数：1

相关论文

共 6 条

[1] RETRACTED: Sedation with GPI 15715, a water-soluble prodrug of propofol, using target-controlled infusion in volunteers (Retracted article. See vol. 110, pg. 1238, 2010) [J].

Fechner, J ;

Ihmsen, H ;

Schiessl, C ;

Jeleazcov, C ;

Vornov, JJ ;

Schwilden, H ;

Schüttler, J .

ANESTHESIA AND ANALGESIA, 2005, 100 (03) :701-706

[2] RETRACTED: Comparative pharmacokinetics and pharmacodynamics of the new propofol prodrug GPI 15715 and propofol emulsion (Retracted article. See vol. 112, pg. 1058, 2010) [J].

Fechner, J ;

Ihmsen, H ;

Hatterscheid, D ;

Jeleazcov, C ;

Schiessl, C ;

Vornov, JJ ;

Schwilden, H ;

Schüttler, J .

ANESTHESIOLOGY, 2004, 101 (03) :626-639

[3] RETRACTED: Pharmacokinetics and clinical pharmacodynamics of the new propofol prodrug GPI 15715 in volunteers (Retracted article. See vol. 112, pg. 1058, 2010) [J].

Fechner, J ;

Ihmsen, H ;

Hatterscheid, D ;

Schiessl, C ;

Vornov, JJ ;

Burak, E ;

Schwilden, H ;

Schüttler, JR .

ANESTHESIOLOGY, 2003, 99 (02) :303-313

[4] RETRACTED: AQUAVANO® injection, a water-soluble prodrug of propofol, as a bolus injection:: A phase I dose-escalation comparison with DIPRIVAN® (Part 1) -: Pharmacokinetics (Retracted article. See vol. 112, pg. 1058, 2010) [J].

Gibiansky, E ;

Struys, MMRF ;

Gibiansky, L ;

Vanluchene, ALG ;

Vornov, J ;

Mortier, EP ;

Burak, E ;

Van Bortel, L .

ANESTHESIOLOGY, 2005, 103 (04) :718-729

[5] RETRACTED: Pharmacokinetics and pharmacodynamics of the new propofol prodrug GPI 15715 in rats (Retracted article. See vol. 20, pg. 182, 2003) [J].

Schywalsky, M ;

Ihmsen, H ;

Tzabazis, A ;

Fechner, J ;

Burak, E ;

Vornov, J ;

Schwilden, H .

EUROPEAN JOURNAL OF ANAESTHESIOLOGY, 2003, 20 (03) :182-190

[6] RETRACTED: AQUAVAN® injection, a water-soluble prodrug of propofol as a bolus injection:: A phase I dose-escalation comparison with DIPRIVAN® (Part 2) -: Pharmacodynamics and safety (Retracted article. See vol. 112, pg. 1058, 2010) [J].

Struys, MMRF ;

Vanluchene, ALG ;

Gibiansky, E ;

Gibiansky, L ;

Vornov, J ;

Mortier, EP ;

Van Bortel, L .

ANESTHESIOLOGY, 2005, 103 (04) :730-743