Risk factors for osteoporosis and fractures in rheumatoid arthritis

被引：44

作者：

Baker, Rahaf ^{[1
]}

Narla, Radhika ^{[2
]}

Baker, Joshua F. ^{[3
]}

Wysham, Katherine D. ^{[4
]}

机构：

[1] Alameda Hlth Syst Internal Med Residency, PGY-2 Internal Med, 1411 13th St, Oakland, CA USA

[2] Univ Washington, Metab Endocrinol & Nutr, VA Puget Sound Hlth Care Syst, 1660 South Columbian Way,UW Mailbox, Seattle, WA USA

[3] Univ Penn, Corporal Michael J Crescenz VA Med Ctr, Rheumatol & Epidemiol, 5 White Bldg,3600 Spruce St, Philadelphia, PA 19104 USA

[4] Univ Washington, Div Rheumatol, Rheumatol Sect, VA Puget Sound Hlth Care Syst, 1660 South Columbian Way,S-151-A, Seattle, WA 98108 USA

来源：

BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY | 2022年 / 36卷 / 03期

关键词：

Rheumatoid arthritis; Fracture; Osteoporosis; Body composition; Falls; BONE-MINERAL DENSITY; CITRULLINATED PROTEIN ANTIBODIES; POSTMENOPAUSAL WOMEN; HIP FRACTURE; LEAN MASS; FALLS; MUSCLE; ADULTS; MEN; PREVALENCE;

D O I：

10.1016/j.berh.2022.101773

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

People with rheumatoid arthritis (RA) have both disease-specific risk factors for osteoporosis and fractures in addition to those that affect the general population. Disease specific risks include directly pathogenic auto-antibodies, chronic exposure to systemic inflammation, and joint damage causing early disability. Risk fac-tors that affect the general population which may have a higher prevalence in RA include smoking, calcium and vitamin D defi-ciency as well as hypogonadism. Additionally, chronic exposure to glucocorticoids results in reduced bone mineral density and body composition changes which can further increase fracture risk. In this review we discuss these risk-factors for osteoporosis as well as factors that may impact fall and fracture risk in people with RA. Published by Elsevier Ltd.

引用

页数：9

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