Requirement for the Transcription Factor LSIRF/IRF4 for Mature B and T Lymphocyte Function

被引：496

作者：

Mittrucker, Hans-Willi ^{[1
,2
,3
]}

Matsuyama, Toshifumi ^{[4
]}

Grossman, Alex ^{[1
,2
,3
]}

Kundig, Thomas M. ^{[1
,2
,3
]}

Potter, Julia ^{[1
,2
,3
]}

Shahinian, Arda ^{[1
,2
,3
]}

Wakeham, Andrew ^{[1
,2
,3
]}

Patterson, Bruce ^{[5
]}

Ohashi, Pamela S. ^{[1
,2
,3
]}

Mak, Tak W. ^{[1
,2
,3
]}

机构：

[1] Univ Toronto, Dept Immunol, 610 Univ Ave, Toronto, ON M5G 2C1, Canada

[2] Univ Toronto, Dept Med Biophys, 610 Univ Ave, Toronto, ON M5G 2C1, Canada

[3] Amgen Inst, 610 Univ Ave, Toronto, ON M5G 2C1, Canada

[4] Nagasaki Univ, Dept Oncol, Fac Med, Nagasaki, Japan

[5] Ontario Canc Inst, Dept Oncol Pathol, 610 Univ Ave, Toronto, ON M5G 2C1, Canada

来源：

JOURNAL OF IMMUNOLOGY | 2017年 / 199卷 / 11期

关键词：

D O I：

10.1126/science.275.5299.540

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Lymphocyte-specific interferon regulatory factor (LSIRF) (now called IRF4) is a transcription factor expressed only in lymphocytes. Mice deficient in IRF4 showed normal distribution of B and T lymphocyes at 4 to 5 weeks of age but developed progressive generalized lymphadenopathy. IRF4-deficient mice exhibited a profound reduction in serum immunoglobulin concentrations and did not mount detectable antibody responses. T lymphocyte function was also impaired in vivo: these mice could not generate cytotoxic or antitumor responses. Thus, IRF4 is essential for the function and homeostasis of both mature B and mature T lymphocytes.

引用

页码：3717 / 3720

页数：4

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