Nephrotoxicity of contrast media and protective effects of acetylcysteine (vol 85, pg 165, 2011)

被引：3

作者：

Briguori, Carlo ^{[1
]}

Quintavalle, Cristina ^{[2
]}

De Micco, Francesca ^{[3
]}

Condorelli, Gerolama ^{[4
,5
]}

机构：

[1] Clin Mediterranea, Lab Intervent Cardiol, I-80121 Naples, Italy

[2] Fdn SDN, I-80143 Naples, Italy

[3] IRCCS Multimed, Milan, Italy

[4] Univ Naples Federico 2, Dept Cellular & Mol Biol & Pathol, I-80131 Naples, Italy

[5] Univ Naples Federico 2, CNR, IEOS, I-80131 Naples, Italy

来源：

ARCHIVES OF TOXICOLOGY | 2011年 / 85卷 / 03期

关键词：

Acetylcysteine; Apoptosis; Contrast media; Kidney; NAC;

D O I：

10.1007/s00204-011-0647-8

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

Contrast-induced acute kidney injury (CI-AKI) accounts for approximately 10% of all causes of hospital-acquired renal failure, causes a prolonged in-hospital stay, and represents a powerful predictor of poor early and late outcome. N-acetylcysteine (NAC) is a thiol compound classically known as a mucolytic agent, which is a potent antioxidant that scavenges a wide variety of oxygen-derived-free-radicals and may be capable of preventing acute kidney injury. In the present study, we will review (1) the pathophysiology of the CI-AKI and (2) the experimental and clinical data on the effects of NAC in preventing CI-AKI.

引用

页码：175 / 175

页数：1