p53 polymorphism and risk of cervical cancer

被引：95

作者：

Hildesheim, A

Schiffman, M

Brinton, LA

Fraumeni, JF

Herrero, R

Bratti, MC

Schwartz, P

Mortel, R

Barnes, W

Greenberg, M

McGowan, L

Scott, DR

Martin, M

Herrera, JE

Carrington, M

机构：

[1] NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA

[2] Int Agcy Res Canc, F-69372 Lyon, France

[3] Caja Costarriciense Seguro Social, San Jose, Costa Rica

[4] Yale Univ, Sch Med, New Haven, CT 06519 USA

[5] Penn State Univ, Milton S Hershey Med Ctr, Hershey, PA 17033 USA

[6] Georgetown Univ, Vincent T Lombardi Canc Res Ctr, Washington, DC 20007 USA

[7] Grad Hosp Philadelphia, Philadelphia, PA 19146 USA

[8] George Washington Univ, Med Ctr, Washington, DC 20037 USA

[9] Kaiser Permanente, Portland, OR 97227 USA

[10] NCI, Intramural Res Support Program, SAIC Frederick, FCRDC, Frederick, MD 21702 USA

来源：

NATURE | 1998年 / 396卷 / 6711期

关键词：

D O I：

10.1038/25040

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Storeyet al. reply — These reports assess the frequency of the p53Arg allele in different populations and conclude that homozygous p53Arg is not a risk factor for cancer associated with human papilloma virus (HPV). The functional differences between the p53 isoforms that we have described1,2 provoked our initial epidemiological study. As we concluded then, it is crucial that investigations should be extended to different populations, and we are encouraged that such studies are underway.

引用

页码：531 / 532

页数：2

共 5 条

[1]

Cullen M, 1997, AM J HUM GENET, V60, P397

[2]

HERRERO R, 1997, PAN AM J PUBLIC HLTH, V1, P362

[3]

Hildesheim A, 1998, CANCER EPIDEM BIOMAR, V7, P1035

[4] ADENOCARCINOMAS OF THE UTERINE CERVIX - THE EPIDEMIOLOGY OF AN INCREASING PROBLEM [J].