Integrins in regulation of tissue development and function (vol 200, pg 471, 2003)

被引：169

作者：

Danen, EHJ ^{[1
]}

Sonnenberg, A ^{[1
]}

机构：

[1] Netherlands Canc Inst, Div Cell Biol, NL-1066 CX Amsterdam, Netherlands

来源：

JOURNAL OF PATHOLOGY | 2003年 / 201卷 / 04期

关键词：

integrin; cell adhesion; signaling; development;

D O I：

10.1002/path.1472

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cell adhesion is indispensable for embryonic development and for proper tissue function. In metazoans, integrins are the major adhesion receptors that connect cells to components of the extracellular matrix. Integrins are implicated in assembly of extracellular matrices, cell adhesion and migration on extracellular matrices, and in vertebrates (in which the integrin family has expanded) they can also mediate cell-cell adhesion. Furthermore, integrin-mediated adhesion can modulate many different signal transduction cascades and support cell survival, proliferation, and influence the expression of differentiation-related genes. In this review we briefly explain how integrins can affect so many different aspects of cell behavior and discuss evidence for roles of integrins in tissue development, function, and disease. Copyright (C) 2003 John Wiley Sons, Ltd.

引用

页码：632 / 641

页数：10

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