Entacapone-induced hepatotoxicity and hepatic dysfunction

被引：28

作者：

Fisher, A

Croft-Baker, J

Davis, M

Purcell, P

McLean, AJ

机构：

[1] Canberra Hosp, Dept Geriatr Med, Canberra, ACT, Australia

[2] Univ Sydney, Sch Clin, Canberra, ACT, Australia

[3] Therapeut Goods Adm, Canberra, ACT, Australia

[4] Univ Melbourne, Royal Melbourne Hosp, Natl Ageing Res Inst, Melbourne, Vic 3050, Australia

[5] Melbourne Hlth, Melbourne, Vic, Australia

来源：

MOVEMENT DISORDERS | 2002年 / 17卷 / 06期

关键词：

hepatotoxicity; entacapone; COMT inhibitors;

D O I：

10.1002/mds.10342

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We describe 2 patients with Parkinson's disease who developed hepatotoxicity associated with the use of entacapone, a novel, mainly peripheral acting inhibitor of catechol-D-methyltransferase. Hepatotoxicity resolved rapidly with discontinuation of the drug. Analysis of causality in a further case initially linked to entacapone exposure was confounded by conflicting serial adverse reaction reports. (C) 2002 Movement Disorder Society.

引用

页码：1362 / 1365

页数：4

共 20 条

[1] SERUM LACTIC-DEHYDROGENASE IN THE DIFFERENTIAL-DIAGNOSIS OF ACUTE HEPATOCELLULAR INJURY [J].