Regulation of cell signalling cascades by steroid hormones

被引:67
作者
Cheskis, BJ [1 ]
机构
[1] Wyeth Res, Womens Hlth Res Inst, Dept Osteoporosis, Collegeville, PA 19426 USA
关键词
nuclear receptors; non-genomic action of nuclear receptors; signal transduction; rapid signaling;
D O I
10.1002/jcb.20180
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Steroid hormones control a wide variety of cellular functions important for cell homeostasis, proliferation, differentiation, and apoptosis. Evidence collected in the last few years indicates that this regulation is mediated by a complex interface of direct control of gene expression (so-called "transcriptional" action, driven by receptors that are localized in cell nucleus) and by regulation of cell signaling/phosphorylation cascades ("extranuclear" action, mediated by receptors that are localized in close proximity to cellular membrane). Regulation of gene expression takes place via ligand-dependent receptor binding to target gene promoters as part of the preinitiation complex, which leads to chromatin remodeling and ultimately regulates the rate of gene expression. Steroid-mediated regulation of cell signaling does not depend on gene transcription or protein biosynthesis. The molecular mechanism of this phenomenon is not fully understood. This review will focus on recent developments related to our understanding of the molecular mechanism of the extranuclear action of steroid hormones. (C) 2004 Wiley-Liss, Inc.
引用
收藏
页码:20 / 27
页数:8
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