Role of intramyocelluar lipids in human health

被引：201

作者：

Coen, Paul M. ^{[1
,2
]}

Goodpaster, Bret H. ^{[1
]}

机构：

[1] Univ Pittsburgh, Div Endocrinol & Metab, Sch Med, Pittsburgh, PA 15213 USA

[2] Univ Pittsburgh, Dept Hlth & Phys Act, Pittsburgh, PA 15260 USA

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2012年 / 23卷 / 08期

关键词：

adipose triglyceride lipase; hormone sensitive lipase; insulin resistance; fatty acids; lipidomics; intramyocellular lipid; ceramide; diacylglycerol; HUMAN SKELETAL-MUSCLE; INDUCED INSULIN-RESISTANCE; FATTY-ACID OXIDATION; ADIPOSE TRIGLYCERIDE LIPASE; HORMONE-SENSITIVE LIPASE; PROTEIN-KINASE-C; WEIGHT-LOSS; CERAMIDE CONTENT; CONTRACTILE ACTIVITY; TRAINING INCREASES;

D O I：

10.1016/j.tem.2012.05.009

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Intramyocellular lipid (MU is predominantly stored as intramuscular triglyceride (IMTG) in lipid droplets and is utilized as metabolic fuel during physical exercise. IMTG is also implicated in muscle insulin resistance (IR) in type 2 diabetes. However, it has become apparent that lipid moieties such as ceramide and diacylglycerol are the likely culprits of IR. This article reviews current knowledge of IMCL-mediated IR and important areas of investigation, including myocellular lipid transport and lipid droplet proteins. Several crucial questions remain unanswered, such as the identity of specific ceramide and diacylglycerol species that mediate IR in human muscle and their subcellular location. Quantitative lipidomics and proteomics of targeted subcellular organelles will help to better define the mechanisms underlying pathological IMCL accumulation and IR.

引用

页码：391 / 398

页数：8

共 100 条

[1] Ceramide content is increased in skeletal muscle from obese insulin-resistant humans [J].

Adams, JM ;

Pratipanawatr, T ;

Berria, R ;

Wang, E ;

DeFronzo, RA ;

Sullards, MC ;

Mandarino, LJ .

DIABETES, 2004, 53 (01) :25-31

[2] Adipose triglyceride lipase in human skeletal muscle is upregulated by exercise training [J].

Alsted, Thomas J. ;

Nybo, Lars ;

Schweiger, Martina ;

Fledelius, Christian ;

Jacobsen, Poul ;

Zimmermann, Robert ;

Zechner, Rudolf ;

Kiens, Bente .

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2009, 296 (03) :E445-E453

[3] Skeletal Muscle Triglycerides, Diacylglycerols, and Ceramides in Insulin Resistance Another Paradox in Endurance-Trained Athletes? [J].

Amati, Francesca ;

Dube, John J. ;

Alvarez-Carnero, Elvis ;

Edreira, Martin M. ;

Chomentowski, Peter ;

Coen, Paul M. ;

Switzer, Galen E. ;

Bickel, Perry E. ;

Stefanovic-Racic, Maja ;

Toledo, Frederico G. S. ;

Goodpaster, Bret H. .

DIABETES, 2011, 60 (10) :2588-2597

[4] Diabetes mellitus is associated with increased intramyocellular triglyceride, but not diglyceride, content in obese humans [J].

Anastasiou, Costas A. ;

Kavouras, Stavros A. ;

Lentzas, Yannis ;

Gova, Afrodite ;

Sidossis, Labros S. ;

Melidonis, Adreas .

METABOLISM-CLINICAL AND EXPERIMENTAL, 2009, 58 (11) :1636-1642

[5] Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans [J].

Anderson, Ethan J. ;

Lustig, Mary E. ;

Boyle, Kristen E. ;

Woodlief, Tracey L. ;

Kane, Daniel A. ;

Lin, Chien-Te ;

Price, Jesse W., III ;

Kang, Li ;

Rabinovitch, Peter S. ;

Szeto, Hazel H. ;

Houmard, Joseph A. ;

Cortright, Ronald N. ;

Wasserman, David H. ;

Neufer, P. Darrell .

JOURNAL OF CLINICAL INVESTIGATION, 2009, 119 (03) :573-581

[6] Effects of intravenous and dietary lipid challenge on intramyocellular lipid content and the relation with insulin sensitivity in humans [J].

Bachmann, OP ;

Dahl, DB ;

Brechtel, K ;

Machann, J ;

Haap, M ;

Maier, T ;

Loviscach, M ;

Stumvoll, M ;

Claussen, CA ;

Schick, F ;

Häring, HU ;

Jacob, S .

DIABETES, 2001, 50 (11) :2579-2584

[7] Altered Skeletal Muscle Lipase Expression and Activity Contribute to Insulin Resistance in Humans [J].

Badin, Pierre-Marie ;

Louche, Katie ;

Mairal, Aline ;

Liebisch, Gerhard ;

Schmitz, Gerd ;

Rustan, Arild C. ;

Smith, Steven R. ;

Langin, Dominique ;

Moro, Cedric .

DIABETES, 2011, 60 (06) :1734-1742

[8] Skeletal muscle lipid oxidation and obesity: influence of weight loss and exercise [J].

Berggren, Jason R. ;

Boyle, Kristen E. ;

Chapman, William H. ;

Houmard, Joseph A. .

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2008, 294 (04) :E726-E732

[9] Localisation and composition of skeletal muscle diacylglycerol predicts insulin resistance in humans [J].

Bergman, B. C. ;

Hunerdosse, D. M. ;

Kerege, A. ;

Playdon, M. C. ;

Perreault, L. .

DIABETOLOGIA, 2012, 55 (04) :1140-1150

[10] Evaluation of exercise and training on muscle lipid metabolism [J].

Bergman, BC ;

Butterfield, GE ;

Wolfel, EE ;

Casazza, GA ;

Lopaschuk, GD ;

Brooks, GA .

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 1999, 276 (01) :E106-E117

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