Pharmacogenetics in drug discovery and development: a translational perspective

被引：99

作者：

Roses, Allen D. ^{[1
,2
]}

机构：

[1] Duke Univ, Med Ctr, Drug Discovery Inst, Durham, NC 27708 USA

[2] Fuqua Sch Business, Durham, NC 27708 USA

来源：

NATURE REVIEWS DRUG DISCOVERY | 2008年 / 7卷 / 10期

关键词：

D O I：

10.1038/nrd2593

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The ability to predict a patient's drug response on the basis of their genetic information is expected to decrease attrition during the development of new, innovative drugs, and reduce adverse events by being able to predict individual patients at risk. Most pharmacogenetic investigations have focused on drug-metabolism genes or candidate genes that are thought to be involved in specific diseases. However, robust new genetic tools now enable researchers to carry out multi-candidate gene-association and genome-wide studies for target discovery and drug development. Despite the expanding role of pharmacogenetics in industry, however, there is a paucity of published data. New forms of effective and efficient collaboration between industry and academia that may enhance the systematic collection of pharmacogenetic data are necessary to establish genetic profiles related to drug response, confirm pharmacogenetic associations and expedite the development of new drugs and diagnostic tests.

引用

页码：807 / 817

页数：11

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