Synthesis and triplex forming properties of pyrimidine derivative containing extended functionality

被引：11

作者：

Gianolio, DA ^{[1
]}

McLaughlin, LW ^{[1
]}

机构：

[1] Merkert Chem Ctr, Dept Chem, Chestnut Hill, MA 02167 USA

来源：

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | 1999年 / 18卷 / 08期

关键词：

D O I：

10.1080/07328319908044841

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Two pyrimidine nucleosides have been synthesized containing extended hydrogen bonding functionality. In one case the side chain is based upon semicarbazide and in the second monoacetylated carbohydrazide was employed. DNA sequences;sequences could be prepared using both analogue nucleosides in a reverse coupling protocol, and provided that the normal capping step was eliminated and that the iodine-based oxidizing solution was replaced with one based upon 10-camphorsulfonyl oxaziridine. Both derivatives exhibited moderate effects in targeting selectively C-G base pairs embedded within a polypurine target sequence.

引用

页码：1751 / 1769

页数：19

共 20 条

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