Asthma: T-bet - A master controller?

被引：39

作者：

Robinson, DS ^{[1
]}

Lloyd, CM

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, Dept Allergy, London SW7 2AZ, England

[2] Univ London Imperial Coll Sci Technol & Med, Fac Med, Div Biomed Sci, London SW7 2AZ, England

来源：

CURRENT BIOLOGY | 2002年 / 12卷 / 09期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/S0960-9822(02)00830-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The transcription factors T-bet and GATA3 are important reciprocal determinants of Th1 and Th2 T helper cell differentiation. Recent evidence suggests that these factors may affect airway immunopathology in asthma.

引用

页码：R322 / R324

页数：3

共 20 条

[1] In vitro generation of interleukin 10-producing regulatory CD4+ T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)- and Th2-inducing cytokines [J].

Barrat, FJ ;

Cua, DJ ;

Boonstra, A ;

Richards, DF ;

Crain, C ;

Savelkoul, HF ;

de Waal-Malefyt, R ;

Coffman, RL ;

Hawrylowicz, CM ;

O'Garra, A .

JOURNAL OF EXPERIMENTAL MEDICINE, 2002, 195 (05) :603-616

[2] Efficacy of soluble IL-4 receptor for the treatment of adults with asthma [J].

Borish, LC ;

Nelson, HS ;

Corren, J ;

Bensch, G ;

Busse, WW ;

Whitmore, JB ;

Agosti, JM .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2001, 107 (06) :963-970

[3] Effects of recombinant human interleukin-12 on eosinophils, airway hyper-responsiveness, and the late asthmatic response [J].

Bryan, SA ;

O'Connor, BJ ;

Matti, S ;

Leckie, MJ ;

Kanabar, V ;

Khan, J ;

Warrington, SJ ;

Renzetti, L ;

Rames, A ;

Bock, JA ;

Boyce, MJ ;

Hansel, TT ;

Holgate, ST ;

Barnes, PJ .

LANCET, 2000, 356 (9248) :2149-2153

[4]

DONG C, 2000, SCI STKE PE1

[5] GATA-3 significantly downregulates IFN-γ production from developing Th1 cells in addition to inducing IL4-and IL-5 levels [J].

Ferber, IA ;

Lee, HJ ;

Zonin, F ;

Heath, V ;

Mui, A ;

Arai, N ;

O'Garra, A .

CLINICAL IMMUNOLOGY, 1999, 91 (02) :134-144

[6] Development of spontaneous airway changes consistent with human asthma in mice lacking T-bet [J].

Finotto, S ;

Neurath, MF ;

Glickman, JN ;

Qin, SX ;

Lehr, HA ;

Green, FHY ;

Ackerman, K ;

Haley, K ;

Gatte, PR ;

Szabo, SJ ;

Drazen, JM ;

De Sanctis, GT ;

Glimcher, LH .

SCIENCE, 2002, 295 (5553) :336-338

[7] Early transcription and silencing of cytokine genes underlie polarization of T helper cell subsets [J].

Grogan, JL ;

Mohrs, M ;

Harmon, B ;

Lacy, DA ;

Sedat, JW ;

Locksley, RM .

IMMUNITY, 2001, 14 (03) :205-215

[8]

Hogan SP, 1998, J IMMUNOL, V161, P1501

[9] Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response [J].

Leckie, MJ ;

ten Brinke, A ;

Khan, J ;

Diamant, Z ;

O'Connor, BJ ;

Walls, CM ;

Mathur, AK ;

Cowley, HC ;

Chung, KF ;

Djukanovic, R ;

Hansel, TT ;

Holgate, T ;

Sterk, PJ ;

Barnes, PJ .

LANCET, 2000, 356 (9248) :2144-2148

[10] T-bet is rapidly induced by interferon-γ in lymphoid and myeloid cells [J].

Lighvani, AA ;

Frucht, DM ;

Jankovic, D ;

Yamane, H ;

Aliberti, J ;

Hissong, BD ;

Nguyen, BV ;

Gadina, M ;

Sher, A ;

Paul, WE ;

O'Shea, JJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (26) :15137-15142

← 1 2 →