Nonprimate Hepaciviruses in Domestic Horses, United Kingdom

被引:90
作者
Lyons, Sinead [1 ]
Kapoor, Amit [2 ]
Sharp, Colin [1 ]
Schneider, Bradley S. [3 ]
Wolfe, Nathan D. [3 ]
Culshaw, Geoff [1 ]
Corcoran, Brendan [1 ]
McGorum, Bruce C. [1 ]
Simmonds, Peter [1 ]
机构
[1] Univ Edinburgh, Edinburgh EH25 9RG, Midlothian, Scotland
[2] Columbia Univ, New York, NY USA
[3] Global Viral Forecasting Initiat, San Francisco, CA USA
关键词
HEPATITIS-C VIRUS; GBV-B; ORIGIN; EPIDEMIOLOGY; INFECTION; VARIANTS; HOMOLOG; MONKEYS; AGENT;
D O I
10.3201/eid1812.120498
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Although the origin of hepatitis C virus infections in humans remains undetermined, a close homolog of this virus, termed canine hepacivirus (CHV) and found in respiratory secretions of dogs, provides evidence for a wider distribution of hepaciviruses in mammals. We determined frequencies of active infection among dogs and other mammals in the United Kingdom. Samples from dogs (46 respiratory, 99 plasma, 45 autopsy samples) were CHV negative by PCR. Screening of 362 samples from cats, horses, donkeys, rodents, and pigs identified 3 (2%) positive samples from 142 horses. These samples were genetically divergent from CHV and nonprimate hepaciviruses that horses were infected with during 2012 in New York state, USA. Investigation of infected horses demonstrated nonprimate hepacivirus persistence, high viral loads in plasma (10(5)-10(7) RNA copies/mL), and liver function test results usually within reference ranges, although several values ranged from high normal to mildly elevated. Disease associations and host range of nonprimate hepaciviruses warrant further investigation.
引用
收藏
页码:1976 / 1982
页数:7
相关论文
共 33 条
[1]   Hybrid origin of SIV in chimpanzees [J].
Bailes, E ;
Gao, F ;
Bibollet-Ruche, F ;
Courgnaud, V ;
Peeters, M ;
Marx, PA ;
Hahn, BH ;
Sharp, PM .
SCIENCE, 2003, 300 (5626) :1713-1713
[2]  
Beames B, 2001, ILAR J, V42, P152
[3]   Host range studies of GB virus-B hepatitis agent, the closest relative of hepatitis C virus, in New World monkeys and chimpanzees [J].
Bukh, J ;
Apgar, CL ;
Govindarajan, S ;
Purcell, RH .
JOURNAL OF MEDICAL VIROLOGY, 2001, 65 (04) :694-697
[4]   Failure to infect rhesus monkeys with hepatitis C virus strains of genotypes 1a, 2a or 3a [J].
Bukh, J ;
Apgar, CL ;
Govindarajan, S ;
Emerson, SU ;
Purcell, RH .
JOURNAL OF VIRAL HEPATITIS, 2001, 8 (03) :228-231
[5]   Hepatitis C homolog in dogs with respiratory illness [J].
Bukh, Jens .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (31) :12563-12564
[6]   Serology-Enabled Discovery of Genetically Diverse Hepaciviruses in a New Host [J].
Burbelo, Peter D. ;
Dubovi, Edward J. ;
Simmonds, Peter ;
Medina, Jan L. ;
Henriquez, Jose A. ;
Mishra, Nischay ;
Wagner, Jason ;
Tokarz, Rafal ;
Cullen, John M. ;
Ladarola, Michael J. ;
Rice, Charles M. ;
Lipkin, W. Ian ;
Kapoor, Amit .
JOURNAL OF VIROLOGY, 2012, 86 (11) :6171-6178
[7]   Frequent recovery and broad genotype 2 diversity characterize hepatitis C virus infection in Ghana, West Africa [J].
Candotti, D ;
Temple, J ;
Sarkodie, F ;
Allain, JP .
JOURNAL OF VIROLOGY, 2003, 77 (14) :7914-7923
[8]   The role of parenteral antischistosomal therapy in the spread of hepatitis C virus in Egypt [J].
Frank, C ;
Mohamed, MK ;
Strickland, GT ;
Lavanchy, D ;
Arthur, RR ;
Magder, LS ;
El Khoby, T ;
Abdel-Wahab, Y ;
Ohn, EA ;
Anwar, W ;
Sallam, I .
LANCET, 2000, 355 (9207) :887-891
[9]   Origin of HIV-1 in the chimpanzee Pan troglodytes troglodytes [J].
Gao, F ;
Bailes, E ;
Robertson, DL ;
Chen, YL ;
Rodenburg, CM ;
Michael, SF ;
Cummins, LB ;
Arthur, LO ;
Peeters, M ;
Shaw, GM ;
Sharp, PM ;
Hahn, BH .
NATURE, 1999, 397 (6718) :436-441
[10]   Immunobiology and pathogenesis of viral hepatitis [J].
Guidotti, Luca G. ;
Chisari, Francis V. .
ANNUAL REVIEW OF PATHOLOGY-MECHANISMS OF DISEASE, 2006, 1 (01) :23-61