Epidermal growth factor receptor and EGFRvIII in glioblastoma: signaling pathways and targeted therapies

被引：539

作者：

An, Zhenyi ^{[1
]}

Aksoy, Ozlem ^{[1
]}

Zheng, Tina ^{[1
]}

Fan, Qi-Wen ^{[1
]}

Weiss, William A. ^{[1
,2
,3
]}

机构：

[1] Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94131 USA

[2] Univ Calif San Francisco, Helen Diller Family Comprehens Canc Ctr, San Francisco, CA 94143 USA

[3] Univ Calif San Francisco, Dept Neurol Surg, San Francisco, CA 94131 USA

来源：

ONCOGENE | 2018年 / 37卷 / 12期

关键词：

PHASE-II; INTRATUMORAL HETEROGENEITY; TYROSINE PHOSPHORYLATION; NUCLEAR TRANSLOCATION; TUMOR-SUPPRESSOR; GLIOMA GROWTH; CELL-SURVIVAL; IN-VITRO; ACTIVATION; AKT;

D O I：

10.1038/s41388-017-0045-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Amplification of epidermal growth factor receptor (EGFR) and its active mutant EGFRvIII occurs frequently in glioblastoma (GBM). While EGFR and EGFRvIII play critical roles in pathogenesis, targeted therapy with EGFR-tyrosine kinase inhibitors (TKIs) or antibodies has only shown limited efficacy in patients. Here we discuss signaling pathways mediated by EGFR/EGFRvIII, current therapeutics, and novel strategies to target EGFR/EGFRvIII-amplified GBM.

引用

页码：1561 / 1575

页数：15

共 149 条

[1]

PKC-η mediates glioblastoma cell proliferation through the Akt and mTOR signaling pathways [J].

Aeder, SE ;

Martin, PM ;

Soh, JW ;

Hussaini, IM .

ONCOGENE, 2004, 23 (56) :9062-9069

[2]

De-Repression of PDGFRβ Transcription Promotes Acquired Resistance to EGFR Tyrosine Kinase Inhibitors in Glioblastoma Patients [J].

Akhavan, David ;

Pourzia, Alexandra L. ;

Nourian, Alex A. ;

Williams, Kevin J. ;

Nathanson, David ;

Babic, Ivan ;

Villa, Genaro R. ;

Tanaka, Kazuhiro ;

Nael, Ali ;

Yang, Huijun ;

Dang, Julie ;

Vinters, Harry V. ;

Yong, William H. ;

Flagg, Mitchell ;

Tamanoi, Fuyuhiko ;

Sasayama, Takashi ;

James, C. David ;

Kornblum, Harley I. ;

Cloughesy, Tim F. ;

Cavenee, Webster K. ;

Bensinger, Steven J. ;

Mischel, Paul S. .

CANCER DISCOVERY, 2013, 3 (05) :534-547

[3]

Intercellular transfer of the oncogenic receptor EGFrvIII by microvesicles derived from tumour cells [J].

Al-Nedawi, Khalid ;

Meehan, Brian ;

Micallef, Johann ;

Lhotak, Vladimir ;

May, Linda ;

Guha, Abhijit ;

Rak, Janusz .

NATURE CELL BIOLOGY, 2008, 10 (05) :619-U24

[4]

Phorbol 12-myristate 13-acetate induces epidermal growth factor receptor transactivation via protein kinase Cδ/c-Src pathways in glioblastoma cells [J].

Amos, S ;

Martin, PM ;

Polar, GA ;

Parsons, SJ ;

Hussaini, IM .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (09) :7729-7738

[5]

[Anonymous], SCI SIGNALING

[6]

Cancer-Associated Protein Kinase C Mutations Reveal Kinase's Role as Tumor Suppressor [J].

Antal, Corina E. ;

Hudson, Andrew M. ;

Kang, Emily ;

Zanca, Ciro ;

Wirth, Christopher ;

Stephenson, Natalie L. ;

Trotter, Eleanor W. ;

Gallegos, Lisa L. ;

Miller, Crispin J. ;

Fumari, Frank B. ;

Hunter, Tony ;

Brognard, John ;

Newton, Alexandra C. .

CELL, 2015, 160 (03) :489-502

[7]

Stereotactic modulation of blood-brain barrier permeability to enhance drug delivery [J].

Appelboom, Geoff ;

Detappe, Alexandre ;

LoPresti, Melissa ;

Kunjachan, Sijumon ;

Mitrasinovic, Stefan ;

Goldman, Serge ;

Chang, Steve D. ;

Tillement, Olivier .

NEURO-ONCOLOGY, 2016, 18 (12) :1601-1609

[8]

ERBB Receptors: From Oncogene Discovery to Basic Science to Mechanism-Based Cancer Therapeutics [J].

Arteaga, Carlos L. ;

Engelman, Jeffrey A. .

CANCER CELL, 2014, 25 (03) :282-303

[9]

EGFR Mutation-Induced Alternative Splicing of Max Contributes to Growth of Glycolytic Tumors in Brain Cancer [J].

Babic, Ivan ;

Anderson, Erik S. ;

Tanaka, Kazuhiro ;

Guo, Deliang ;

Masui, Kenta ;

Li, Bing ;

Zhu, Shaojun ;

Gu, Yuchao ;

Villa, Genaro R. ;

Akhavan, David ;

Nathanson, David ;

Gini, Beatrice ;

Mareninov, Sergey ;

Li, Rui ;

Camacho, Carolina Espindola ;

Kurdistani, Siavash K. ;

Eskin, Ascia ;

Nelson, Stanley F. ;

Yong, William H. ;

Cavenee, Webster K. ;

Cloughesy, Timothy F. ;

Christofk, Heather R. ;

Black, Douglas L. ;

Mische, Paul S. .

CELL METABOLISM, 2013, 17 (06) :1000-1008

[10]

Kinetics of Inhibitor Cycling Underlie Therapeutic Disparities between EGFR-Driven Lung and Brain Cancers [J].

Barkovich, Krister J. ;

Hariono, Sujatmi ;

Garske, Adam L. ;

Zhang, Jie ;

Blair, Jimmy A. ;

Fan, Qi-Wen ;

Shokat, Kevan M. ;

Nicolaides, Theodore ;

Weiss, William A. .

CANCER DISCOVERY, 2012, 2 (05) :450-457

← 1 2 3 4 5 6 7 8 9 10 →