Nickel(0)-mediated [2+2+1] cyclization reaction of chromium carbene complexes and internal alkynes

被引：15

作者：

Barluenga, Jose ^{[1
]}

Barrio, Pablo ^{[1
]}

Riesoro, Lorena ^{[1
]}

Lopez, Luis A. ^{[1
]}

Tomas, Miguel ^{[1
]}

机构：

[1] Univ Oviedo, Inst Univ Quim Organomet Enrique Moles, Unidad Asoc CSIC, Oviedo 33006, Spain

来源：

TETRAHEDRON | 2006年 / 62卷 / 32期

关键词：

carbene complexes; chromium(0); nickel(0); carbene transfer; alkynes; cyclopentadienes; three-component process;

D O I：

10.1016/j.tet.2006.03.117

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Alkyl, aryl, and heteroaryl chromium Fischer carbene complexes undergo Ni(0)-mediated [2+2+1] cyclization reaction with internal unactivated and electron-poor internal alkynes to yield highly substituted cyclopentadienes with complete regioselectivity in most cases. The intramolecular version of this cyclization has been accomplished with 1.8-diphenyl-1.7-octadiyne to produce indene derivatives. This three-component [2+2+1] cyclization represents a very uncommon process in the chemistry of Fischer carbene complexes. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：7547 / 7551

页数：5

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