Co-injection strategies to modify radiation sensitivity and tumor initiation in transgenic Zebrafish

被引：56

作者：

Langenau, D. M. ^{[1
,2
,3
]}

Keefe, M. D. ^{[1
,2
,3
]}

Storer, N. Y. ^{[1
,2
,3
]}

Jette, C. A.

Smith, A. C. H. ^{[1
,2
,3
]}

Ceol, C. J. ^{[1
,2
,3
]}

Bourque, C. ^{[1
,2
,3
]}

Look, A. T.

Zon, L. I. ^{[1
,2
,3
]}

机构：

[1] Childrens Hosp, Stem Cell Program, Boston, MA 02115 USA

[2] Childrens Hosp, Div Hematol Oncol, Boston, MA 02115 USA

[3] Dana Farber Canc Inst, Boston, MA 02115 USA

来源：

ONCOGENE | 2008年 / 27卷 / 30期

关键词：

Myc; ras; heat-shock; T-cell acute lymphoblastic leukemia; rhabdomyosarcoma;

D O I：

10.1038/onc.2008.56

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The zebrafish has emerged as a powerful genetic model of cancer, but has been limited by the use of stable transgenic approaches to induce disease. Here, a co-injection strategy is described that capitalizes on both the numbers of embryos that can be microinjected and the ability of transgenes to segregate together and exert synergistic effects in forming tumors. Using this mosaic transgenic approach, gene pathways involved in tumor initiation and radiation sensitivity have been identified.

引用

收藏

页码：4242 / 4248

页数：7

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