Alterations in eliminative and sexual reflexes after spinal cord injury: defecatory function and development of spasticity in pelvic floor musculature

被引:20
作者
Nout, YS
Leedy, GM
Beattie, MS
Bresnahan, JC [1 ]
机构
[1] Ohio State Univ, Coll Med & Publ Hlth, Lab CNS Repair & Spinal Trauma & Repair Labs, Dept Neurosci, Columbus, OH 43210 USA
[2] Univ Wyoming, Div Social Work, Laramie, WY USA
来源
AUTONOMIC DYSFUNCTION AFTER SPINAL CORD INJURY | 2006年 / 152卷
关键词
D O I
10.1016/S0079-6123(05)52024-7
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Spinal cord injury often results in loss of normal eliminative and sexual functions. This chapter is focused on defecatory function, although aspects of micturition and erectile function will be covered as well due to the overlap in anatomical organization and response to injury. These systems have both autonomic and somatic components, and are organized in the thoracolumbar (sympathetic), lumbosacral (somatic), and sacral (parasympathetic) spinal cord. Loss of supraspinal descending control and plasticity-mediated alterations at the level of the spinal cord, result in loss of voluntary control and in abnormal functioning of these systems including the development of dyssynergies and spasticity. There are several useful models of spinal cord injury in rodents that exhibit many of the autonomic dysfunctions observed after spinal cord injury in humans. Numerous studies involving these animal models have demonstrated development of abnormalities in bladder, external anal sphincter, and erectile function, such as detrusor sphincter-dyssynergia and external anal sphincter hyperreflexia. Here we review many of these studies and show some of the anatomical alterations that develop within the spinal cord during the development of these hyperreflexias. Furthermore, we show that spasticity develops in other pelvic floor Musculature as well, such as the bulbospongiosus muscle, which results in increased duration and magnitude of pressures developed during erectile events and increased duration of micturition. Advances and continued improvement in the use of current animal models of spinal cord injury should encourage and increase the laboratory work devoted to this relatively neglected area of experimental spinal cord injury.
引用
收藏
页码:359 / 372
页数:14
相关论文
共 91 条
[1]   Targeting recovery: Priorities of the spinal cord-injured population [J].
Anderson, KD .
JOURNAL OF NEUROTRAUMA, 2004, 21 (10) :1371-1383
[2]   THYROTROPIN-RELEASING-HORMONE IN SPINAL-CORD - COEXISTENCE WITH SEROTONIN AND WITH SUBSTANCE-P IN FIBERS AND TERMINALS APPOSING IDENTIFIED PREGANGLIONIC SYMPATHETIC NEURONS [J].
APPEL, NM ;
WESSENDORF, MW ;
ELDE, RP .
BRAIN RESEARCH, 1987, 415 (01) :137-143
[3]   5-HYDROXYTRYPTAMINE, SUBSTANCE-P, AND THYROTROPIN-RELEASING-HORMONE IN THE ADULT CAT SPINAL-CORD SEGMENT L7 - IMMUNOHISTOCHEMICAL AND CHEMICAL STUDIES [J].
ARVIDSSON, U ;
CULLHEIM, S ;
ULFHAKE, B ;
BENNETT, GW ;
FONE, KCF ;
CUELLO, AC ;
VERHOFSTAD, AAJ ;
VISSER, TJ ;
HOKFELT, T .
SYNAPSE, 1990, 6 (03) :237-270
[4]   AFFERENT AND SYMPATHETIC NEURONS PROJECTING INTO LUMBAR VISCERAL NERVES OF THE MALE-RAT [J].
BARON, R ;
JANIG, W .
JOURNAL OF COMPARATIVE NEUROLOGY, 1991, 314 (03) :429-436
[5]  
Basu S, 2004, J ANDROL, V25, P250
[6]  
Beattie MS, 2000, PROG BRAIN RES, V128, P9
[7]   MOTONEURONS INNERVATING THE EXTERNAL ANAL AND URETHRAL SPHINCTERS OF THE FEMALE CAT HAVE DIFFERENT PATTERNS OF DENDRITIC ARBORIZATION [J].
BEATTIE, MS ;
LI, Q ;
LEEDY, MG ;
BRESNAHAN, JC .
NEUROSCIENCE LETTERS, 1990, 111 (1-2) :69-74
[8]   EVIDENCE FOR ALTERATIONS OF SYNAPTIC INPUTS TO SACRAL SPINAL REFLEX CIRCUITS AFTER SPINAL-CORD TRANSECTION IN THE CAT [J].
BEATTIE, MS ;
LEEDY, MG ;
BRESNAHAN, JC .
EXPERIMENTAL NEUROLOGY, 1993, 123 (01) :35-50
[9]  
BEATTIE MS, 1996, SOC NEUR ABSTR, V22
[10]   Velocity-dependent ankle torque in rats after contusion injury of the midthoracic spinal cord: Time course [J].
Bose, P ;
Parmer, R ;
Thompson, FJ .
JOURNAL OF NEUROTRAUMA, 2002, 19 (10) :1231-1249