Efficient method for synthesis of angucyclinone antibiotics via gold-catalyzed intramolecular [4+2] benzannulation:: Enantioselective total synthesis of (+)-ochromycinone and (+)-rubiginone B2

被引：117

作者：

Sato, K ^{[1
]}

Asao, N ^{[1
]}

Yamamoto, Y ^{[1
]}

机构：

[1] Tohoku Univ, Grad Sch Sci, Dept Chem, Sendai, Miyagi 9808578, Japan

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2005年 / 70卷 / 22期

关键词：

D O I：

10.1021/jo051444m

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient synthetic approach to angucyclinone antibiotics, (+)-ochromycinone and (+)-rubiginone B-2, is reported. The key step involves the facile formation of 2,3-dihydrophenantren-4(1H)-one skeleton, an important framework of angucyclinone natural products, by using gold-catalyzed intramolecular [4 + 2] benzannulation reaction.

引用

页码：8977 / 8981

页数：5

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