Biomarkers for the diagnosis of acute kidney injury

被引:74
作者
Waikar, Sushrut S. [1 ]
Bonventre, Joseph V. [1 ]
机构
[1] Harvard Univ, Sch Med, Brigham & Womens Hosp, Dept Med,Renal Div, Boston, MA 02115 USA
来源
NEPHRON CLINICAL PRACTICE | 2008年 / 109卷 / 04期
关键词
acute kidney injury; acute renal failure; biomarker; diagnosis;
D O I
10.1159/000142928
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
The identification of acute kidney injury relies on tests like blood urea nitrogen and serum creatinine that were identified and incorporated into clinical practice several decades ago. This review summarizes clinical studies of newer biomarkers that may permit earlier and more accurate identification of acute kidney injury. The urine may contain sensitive and specific markers of kidney injury that are present due to either impaired tubular reabsorption and catabolism of filtered molecules or release of tubular cell proteins in response to ischemic or nephrotoxic injury. Many potential markers have been studied. Promising injury markers in the urine include N-acetyl-beta-D-glucosaminidase, neutrophil gelatinase-associated lipocalin, kidney injury molecule-1, and interleukin-18. New biomarkers of kidney injury hold the promise of substantially improving the diagnostic approach to acute kidney injury. Adequately powered clinical studies of multiple biomarkers are needed to qualify the biomarkers before they can be fully adopted in clinical practice. Once adopted, more sensitive biomarkers of acute kidney injury hold the potential to transform the care of patients with renal disease. Copyright (C) 2008 S. Karger AG, Basel.
引用
收藏
页码:C192 / C197
页数:6
相关论文
共 36 条
[1]   Urinary biochemistry and microscopy in septic acute renal failure: A systematic review [J].
Bagshaw, Sean M. ;
Langenberg, Christoph ;
Bellomo, Rinaldo .
AMERICAN JOURNAL OF KIDNEY DISEASES, 2006, 48 (05) :695-705
[2]   Shedding of kidney injury molecule-1, a putative adhesion protein involved in renal regeneration [J].
Bailly, V ;
Zhang, ZW ;
Meier, W ;
Cate, R ;
Sanicola, M ;
Bonventre, JV .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (42) :39739-39748
[3]   URINARY ENZYMES IN ACUTE-RENAL-FAILURE [J].
CHEW, SL ;
LINS, RL ;
DAELEMANS, R ;
NUYTS, GD ;
DEBROE, ME .
NEPHROLOGY DIALYSIS TRANSPLANTATION, 1993, 8 (06) :507-511
[4]   Urinary protein and enzyme excretion as markers of tubular damage [J].
D'Amico, G ;
Bazzi, C .
CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION, 2003, 12 (06) :639-643
[5]   Plasma neutrophil gelatinase-associated lipocalin predicts acute kidney injury, morbidity and mortality after pediatric cardiac surgery: a prospective uncontrolled cohort study [J].
Dent, Catherine L. ;
Ma, Qing ;
Dastrala, Sudha ;
Bennett, Michael ;
Mitsnefes, Mark M. ;
Barasch, Jonathan ;
Devarajan, Prasad .
CRITICAL CARE, 2007, 11 (06)
[6]  
Dieterle F., 2007, TOXICOLOGIST, V96, P383
[7]   Urinary measurement of Na+/H+ exchanger isoform 3 (NHE3) protein as new marker of tubule injury in critically ill patients with ARF [J].
du Cheyron, D ;
Daubin, C ;
Poggioli, J ;
Ramakers, M ;
Houillier, P ;
Charbonneau, P ;
Paillard, M .
AMERICAN JOURNAL OF KIDNEY DISEASES, 2003, 42 (03) :497-506
[8]   Small increases in the urinary excretion of glutathione S-transferase A1 and P1 after cardiac surgery are not associated with clinically relevant renal injury [J].
Eijkenboom, JJA ;
van Eijk, LTGJ ;
Pickkers, P ;
Peters, WHM ;
Wetzels, JFM ;
van der Hoeven, HG .
INTENSIVE CARE MEDICINE, 2005, 31 (05) :664-667
[9]   Urinary IL-18: A marker of contrast-induced nephropathy following percutaneous coronary intervention? [J].
Gul, Cuma Bulent ;
Gullulu, Mustafa ;
Oral, Barboros ;
Aydinlar, Ali ;
Oz, Ozen ;
Budak, Ferah ;
Yilmaz, Yusuf ;
Yurtkuran, Mustafa .
CLINICAL BIOCHEMISTRY, 2008, 41 (7-8) :544-547
[10]  
Hamada Yoshiro, 1999, Journal of Medicine (Westbury), V30, P329