From dual binding site acetylcholinesterase inhibitors to multi-target-directed ligands (MTDLs): A step forward in the treatment of Alzheimer's disease

被引：60

作者：

Bolognesi, Maria Laura ^{[1
]}

Minarini, Anna ^{[1
]}

Rosini, Michela ^{[1
]}

Tumiatti, Vincenzo ^{[1
]}

Melchiorre, Carlo ^{[1
]}

机构：

[1] Univ Bologna, Dept Pharmaceut Sci, Alma Mater Studiorum, I-40126 Bologna, Italy

来源：

MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2008年 / 8卷 / 10期

关键词：

dimeric compounds; bivalent ligands; multimodal therapeutics; multifunctional compounds; multifactorial diseases;

D O I：

10.2174/138955708785740652

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Alzheimer's disease is a complex neurodegenerative disorder with a multifaceted pathogenesis. This fact has long halted the development of effective anti-Alzheimer drugs. Recently, however, basis for a therapeutic strategy based on multi-target-directed ligands has been formed. In this context, dual binding site acetylcholinesterase inhibitors represent a suitable starting point. The rational modification of their structures to provide them with additional biological properties has emerged as a successful approach.

引用

页码：960 / 967

页数：8

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