Use of the Syrian Hamster as a New Model of Ebola Virus Disease and Other Viral Hemorrhagic Fevers

被引：46

作者：

Wahl-Jensen, Victoria ^{[1
]}

Bollinger, Laura ^{[1
]}

Safronetz, David ^{[2
]}

de Kok-Mercado, Fabian ^{[2
]}

Scott, Dana P. ^{[2
]}

Ebihara, Hideki ^{[2
]}

机构：

[1] NIAID, Integrated Res Facil Ft Detrick, NIH, Frederick, MD 21702 USA

[2] NIAID, Integrated Res Facil, Rocky Mt Labs, NIH, Hamilton, MT 59840 USA

来源：

VIRUSES-BASEL | 2012年 / 4卷 / 12期

关键词：

Ebola; filovirus; hamster model; rodent model; pathogenesis; PROTECT GUINEA-PIGS; GOLDEN-HAMSTER; GENE-EXPRESSION; MESOCRICETUS-AURATUS; NONHUMAN-PRIMATES; CLINICAL-OBSERVATIONS; IMMUNE-RESPONSES; LETHAL INFECTION; PASSIVE TRANSFER; ANIMAL-MODEL;

D O I：

10.3390/v4123754

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Historically, mice and guinea pigs have been the rodent models of choice for therapeutic and prophylactic countermeasure testing against Ebola virus disease (EVD). Recently, hamsters have emerged as a novel animal model for the in vivo study of EVD. In this review, we discuss the history of the hamster as a research laboratory animal, as well as current benefits and challenges of this model. Availability of immunological reagents is addressed. Salient features of EVD in hamsters, including relevant pathology and coagulation parameters, are compared directly with the mouse, guinea pig and nonhuman primate models.

引用

页码：3754 / 3784

页数：31

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