CREB modulates excitability of nucleus accumbens neurons

被引：265

作者：

Dong, Y

Green, T

Saal, D

Marie, H

Neve, R

Nestler, EJ

Malenka, RC ^{[1
]}

机构：

[1] Stanford Univ, Dept Psychiat & Behav Sci, Nancy Pritzker Lab, Palo Alto, CA 94304 USA

[2] Univ Texas, SW Med Ctr, Dept Psychiat, Dallas, TX 75390 USA

[3] Univ Texas, SW Med Ctr, Ctr Basic Neurosci, Dallas, TX 75390 USA

[4] Harvard Univ, Dept Genet, Cambridge, MA 02478 USA

[5] Harvard Univ, McClean Hosp, Cambridge, MA 02478 USA

来源：

NATURE NEUROSCIENCE | 2006年 / 9卷 / 04期

关键词：

D O I：

10.1038/nn1661

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Drugs of abuse cause activation of the cyclic AMP response element binding protein (CREB) in the nucleus accumbens (NAc). Expression of active CREB in rat NAc medium spiny neurons (MSNs) increased their excitability, whereas dominant-negative CREB had the opposite effect. Decreasing excitability of NAc MSNs in vivo by overexpression of potassium channels enhanced locomotor responses to cocaine, suggesting that the increased NAc MSN excitability caused by CREB helped to limit behavioral sensitivity to cocaine.

引用

页码：475 / 477

页数：3

共 13 条

[1] The many faces of CREB [J].