Tryptophan catabolism and T-cell tolerance: immunosuppression by starvation?

被引：606

作者：

Mellor, AL ^{[1
]}

Munn, DH ^{[1
]}

机构：

[1] Med Coll Georgia, Inst Mol Med & Genet, Mol Immunol Program, Augusta, GA 30912 USA

来源：

IMMUNOLOGY TODAY | 1999年 / 20卷 / 10期

关键词：

D O I：

10.1016/S0167-5699(99)01520-0

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

Some macrophages inhibit microbial infections by producing indoleamine 2,3 dioxygenase (IDO), which catabolizes tryptophan. Here, Andrew Mellor and David Munn discuss evidence that cells that synthesize IDO protect the mammalian fetus from maternal T-cell attack and argue that this mechanism might have wider implications for the control of T-cell responses.

引用

页码：469 / 473

页数：5

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