Regulation of gene expression by the proto-oncogene BCL-6

被引:66
作者
Dent, AL [1 ]
Vasanwala, FH
Toney, LM
机构
[1] Indiana Univ, Sch Med, Dept Microbiol & Immunol, Indianapolis, IN 46202 USA
[2] Indiana Univ, Sch Med, Walther Canc Inst, Indianapolis, IN 46202 USA
关键词
BCL-6; BCL-6-target genes; lymphoma; transcriptional regulation;
D O I
10.1016/S1040-8428(01)00164-0
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The proto-oncogene BCL-6 encodes a transcriptional repressor protein that is expressed at high levels in germinal center B cells and lymphomas with a germinal center B cell phenotype. The BCL-6 gene is a frequent target of chromosomal translocations, micro-deletions, and point mutations in non-Hodgkin's lymphoma. Studies of BCL-6-deficient mice have revealed that BCL-6 is critical for normal lymphocyte differentiation and also that BCL-6 is a negative regulator of inflammation. Recent studies have shed light on how BCL-6 controls these processes by showing that BCL-6 regulates a broad spectrum of target genes. BCL-6 represses transcription of genes involved in lymphocyte activation, differentiation, proliferation, and migration. Although much progress has been made in understanding gene regulation by BCL-6, many important questions are unresolved. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码:1 / 9
页数:9
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