End-joining, translocations and cancer

被引：266

作者：

Bunting, Samuel F. ^{[1
]}

Nussenzweig, Andre ^{[2
]}

机构：

[1] Rutgers State Univ, Ctr Adv Biotechnol & Med, Piscataway, NJ 08854 USA

[2] NIH, Lab Genome Integr, Bethesda, MD 20892 USA

来源：

NATURE REVIEWS CANCER | 2013年 / 13卷 / 07期

基金：

美国国家卫生研究院;

关键词：

DOUBLE-STRAND BREAKS; CLASS SWITCH RECOMBINATION; DNA-DAMAGE-RESPONSE; BALANCED CHROMOSOME REARRANGEMENTS; FRAGILE SITE INSTABILITY; CYTIDINE DEAMINASE AID; HOMOLOGOUS RECOMBINATION; NONHOMOLOGOUS RECOMBINATION; SACCHAROMYCES-CEREVISIAE; GENOMIC INSTABILITY;

D O I：

10.1038/nrc3537

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Fusion genes that are caused by chromosome translocations have been recognized for several decades as drivers of deregulated cell growth in certain types of cancer. In recent years, oncogenic fusion genes have been found in many haematological and solid tumours, demonstrating that translocations are a common cause of malignancy. Sequencing approaches have now confirmed that numerous, non-clonal translocations are a typical feature of cancer cells. These chromosome rearrangements are often highly complex and contain DNA sequence from multiple genomic sites. The factors and pathways that promote translocations are becoming clearer, with non-homologous end-joining implicated as a key source of genomic rearrangements.

引用

页码：443 / 454

页数：12

共 130 条

[1] Preventing Nonhomologous End Joining Suppresses DNA Repair Defects of Fanconi Anemia [J].

Adamo, Adele ;

Collis, Spencer J. ;

Adelman, Carrie A. ;

Silva, Nicola ;

Horejsi, Zuzana ;

Ward, Jordan D. ;

Martinez-Perez, Enrique ;

Boulton, Simon J. ;

La Volpe, Adriana .

MOLECULAR CELL, 2010, 39 (01) :25-35

[2] Common fragile sites as targets for chromosome rearrangements [J].

Arlt, Martin F. ;

Durkin, Sandra G. ;

Ragland, Ryan L. ;

Glover, Thomas W. .

DNA REPAIR, 2006, 5 (9-10) :1126-1135

[3] Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice [J].

Artandi, SE ;

Chang, S ;

Lee, SL ;

Alson, S ;

Gottlieb, GJ ;

Chin, L ;

DePinho, RA .

NATURE, 2000, 406 (6796) :641-645

[4] Telomeres and telomerase in cancer [J].

Artandi, Steven E. ;

DePinho, Ronald A. .

CARCINOGENESIS, 2010, 31 (01) :9-18

[5]

Ayoub N, 2009, CELL CYCLE, V8, P2945

[6] HP1α recruitment to DNA damage by p150CAF-1 promotes homologous recombination repair [J].

Baldeyron, Celine ;

Soria, Gaston ;

Roche, Daniele ;

Cook, Adam J. L. ;

Almouzni, Genevieve .

JOURNAL OF CELL BIOLOGY, 2011, 193 (01) :81-95

[7] Identification of Early Replicating Fragile Sites that Contribute to Genome Instability [J].

Barlow, Jacqueline H. ;

Faryabi, Robert B. ;

Callen, Elsa ;

Wong, Nancy ;

Malhowski, Amy ;

Chen, Hua Tang ;

Gutierrez-Cruz, Gustavo ;

Sun, Hong-Wei ;

McKinnon, Peter ;

Wright, George ;

Casellas, Rafael ;

Robbiani, Davide F. ;

Staudt, Louis ;

Fernandez-Capetillo, Oscar ;

Nussenzweig, Andre .

CELL, 2013, 152 (03) :620-632

[8] DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis [J].

Bartkova, J ;

Horejsi, Z ;

Koed, K ;

Krämer, A ;

Tort, F ;

Zieger, K ;

Guldberg, P ;

Sehested, M ;

Nesland, JM ;

Lukas, C ;

Orntoft, T ;

Lukas, J ;

Bartek, J .

NATURE, 2005, 434 (7035) :864-870

[9] Integrated genomic analyses of ovarian carcinoma [J].

Bell, D. ;

Berchuck, A. ;

Birrer, M. ;

Chien, J. ;

Cramer, D. W. ;

Dao, F. ;

Dhir, R. ;

DiSaia, P. ;

Gabra, H. ;

Glenn, P. ;

Godwin, A. K. ;

Gross, J. ;

Hartmann, L. ;

Huang, M. ;

Huntsman, D. G. ;

Iacocca, M. ;

Imielinski, M. ;

Kalloger, S. ;

Karlan, B. Y. ;

Levine, D. A. ;

Mills, G. B. ;

Morrison, C. ;

Mutch, D. ;

Olvera, N. ;

Orsulic, S. ;

Park, K. ;

Petrelli, N. ;

Rabeno, B. ;

Rader, J. S. ;

Sikic, B. I. ;

Smith-McCune, K. ;

Sood, A. K. ;

Bowtell, D. ;

Penny, R. ;

Testa, J. R. ;

Chang, K. ;

Dinh, H. H. ;

Drummond, J. A. ;

Fowler, G. ;

Gunaratne, P. ;

Hawes, A. C. ;

Kovar, C. L. ;

Lewis, L. R. ;

Morgan, M. B. ;

Newsham, I. F. ;

Santibanez, J. ;

Reid, J. G. ;

Trevino, L. R. ;

Wu, Y. -Q. ;

Wang, M. .

NATURE, 2011, 474 (7353) :609-615

[10] Melanoma genome sequencing reveals frequent PREX2 mutations [J].

Berger, Michael F. ;

Hodis, Eran ;

Heffernan, Timothy P. ;

Deribe, Yonathan Lissanu ;

Lawrence, Michael S. ;

Protopopov, Alexei ;

Ivanova, Elena ;

Watson, Ian R. ;

Nickerson, Elizabeth ;

Ghosh, Papia ;

Zhang, Hailei ;

Zeid, Rhamy ;

Ren, Xiaojia ;

Cibulskis, Kristian ;

Sivachenko, Andrey Y. ;

Wagle, Nikhil ;

Sucker, Antje ;

Sougnez, Carrie ;

Onofrio, Robert ;

Ambrogio, Lauren ;

Auclair, Daniel ;

Fennell, Timothy ;

Carter, Scott L. ;

Drier, Yotam ;

Stojanov, Petar ;

Singer, Meredith A. ;

Voet, Douglas ;

Jing, Rui ;

Saksena, Gordon ;

Barretina, Jordi ;

Ramos, Alex H. ;

Pugh, Trevor J. ;

Stransky, Nicolas ;

Parkin, Melissa ;

Winckler, Wendy ;

Mahan, Scott ;

Ardlie, Kristin ;

Baldwin, Jennifer ;

Wargo, Jennifer ;

Schadendorf, Dirk ;

Meyerson, Matthew ;

Gabriel, Stacey B. ;

Golub, Todd R. ;

Wagner, Stephan N. ;

Lander, Eric S. ;

Getz, Gad ;

Chin, Lynda ;

Garraway, Levi A. .

NATURE, 2012, 485 (7399) :502-506

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