Emergence of autologous neutralization-resistant variants from preexisting human immunodeficiency virus (HIV) quasi species during virus rebound in HIV type 1-infected patients undergoing highly active antiretroviral therapy

被引：16

作者：

Wang, FX

Kimura, T

Nishihara, K

Yoshimura, K

Koito, A

Matsushita, S ^{[1
]}

机构：

[1] Kumamoto Univ, Ctr AIDS Res, Div Clin Retrovirol & Infect Dis, Kumamoto 8600811, Japan

[2] Kumamoto Univ, Grad Sch Sci & Technol, Dept Mat & Life Sci, Kumamoto 8600811, Japan

来源：

JOURNAL OF INFECTIOUS DISEASES | 2002年 / 185卷 / 05期

关键词：

D O I：

10.1086/339015

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The role of neutralizing antibodies (NAbs) during virus rebound in human immunodeficiency virus type 1 (HIV-1)-infected patients undergoing highly active antiretroviral therapy is poorly understood. Three patients in this study had NAbs to preexisting autologous HIV-1 and an episode of virus rebound after a prolonged period of virus suppression. To investigate the influence of NAbs on virus evolution, envelope genotypes of preexisting and rebound viruses were examined. Phylogenetic analysis of env (V1-V5) sequences indicated that rebound viruses had evolved from or preexisted in baseline populations. By use of envelope pseudotype viruses, rebound viruses were found to be significantly resistant to neutralization by autologous antibody in all 3 patients, indicating that rebound viruses were selected by NAbs. The site responsible for conferring neutralization resistance against autologous antibody was identified in the upstream C3 region in 2 of 3 patients.

引用

页码：608 / 617

页数：10

共 34 条

[1] RAPID DEVELOPMENT OF ISOLATE-SPECIFIC NEUTRALIZING ANTIBODIES AFTER PRIMARY HIV-1 INFECTION AND CONSEQUENT EMERGENCE OF VIRUS VARIANTS WHICH RESIST NEUTRALIZATION BY AUTOLOGOUS SERA [J].