A reference system for urinary albumin: current status

被引：46

作者：

Lieske, John C. ^{[1
]}

Bondar, Olga ^{[1
]}

Miller, W. Greg ^{[2
]}

Bachmann, Lorin M. ^{[2
]}

Narva, Andrew S. ^{[3
]}

Itoh, Yoshihisa ^{[4
]}

Zegers, Ingrid ^{[5
]}

Schimmel, Heinz ^{[5
]}

Phinney, Karen ^{[6
]}

Bunk, David M. ^{[6
]}

机构：

[1] Mayo Clin, Renal Funct Lab, Dept Lab Med & Pathol, Div Nephrol & Hypertens,Dept Internal Med, Rochester, MN 55905 USA

[2] Virginia Commonwealth Univ, Dept Pathol, Richmond, VA USA

[3] Natl Inst Diabet & Digest Dis, Natl Kidney Dis Educ Program, NIH, Bethesda, MD USA

[4] Asahikawa Med Coll, Dept Lab Med, Asahikawa, Hokkaido 078, Japan

[5] Commiss European Communities, Joint Res Ctr, IRMM, Geel, Belgium

[6] NIST, Div Analyt Chem, Gaithersburg, MD 20899 USA

来源：

CLINICAL CHEMISTRY AND LABORATORY MEDICINE | 2013年 / 51卷 / 05期

关键词：

chronic kidney disease; microalbumin; reference material; reference method; urine albumin; MASS-SPECTROMETRY; SERUM-ALBUMIN; STANDARDIZATION; QUANTIFICATION;

D O I：

10.1515/cclm-2012-0768

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

100118 [医学信息学]; 100208 [临床检验诊断学];

摘要：

Background: Increased urinary excretion of albumin reflects kidney damage and is a recognized risk factor for progression of renal and cardiovascular disease. Considerable inter-method differences have been reported for both albumin and creatinine measurement results, and therefore the albumin-to-creatinine ratio. Measurement accuracy is unknown and there are no independent reference measurement procedures for albumin and no reference materials for either measurand in urine. Methods: The National Kidney Disease Education Program (NKDEP) Laboratory Working Group and the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) have initiated joint projects to facilitate standardization of urinary albumin and creatinine measurement. Results: A candidate LC-MS/MS reference measurement procedure for urinary albumin and candidate reference materials for urinary albumin and creatinine has been developed. The status of validations of these reference system components is reported. Conclusions: The development of certified reference materials and reference measurement procedures for urinary albumin will enable standardization of this important measurand.

引用

页码：981 / 989

页数：9

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