CD4-independent binding of SIV gp120 to rhesus CCR5

被引：103

作者：

Martin, KA

Wyatt, R

Farzan, M

Choe, H

Marcon, L

Desjardins, E

Robinson, J

Sodroski, J

Gerard, C

Gerard, NP

机构：

[1] DANA FARBER CANC INST,DIV HUMAN RETROVIROL,BOSTON,MA 02115

[2] HARVARD UNIV,SCH MED,CHILDRENS HOSP,PERLMUTTER LAB,DEPT MED,BOSTON,MA 02115

[3] HARVARD UNIV,SCH MED,DEPT PATHOL,BOSTON,MA 02115

[4] UNIV PADUA,SCH MED,INST MICROBIOL,I-35121 PADUA,ITALY

[5] HARVARD UNIV,SCH PUBL HLTH,DEPT CANC BIOL,BOSTON,MA 02115

[6] TULANE UNIV,MED CTR,DEPT PEDIAT,NEW ORLEANS,LA 70112

[7] BETH ISRAEL DEACONESS HOSP,DEPT MED,CHILDRENS HOSP,PERLMUTTER LAB,BOSTON,MA 02115

[8] BETH ISRAEL DEACONESS HOSP,DEPT PEDIAT,CHILDRENS HOSP,PERLMUTTER LAB,BOSTON,MA 02115

来源：

SCIENCE | 1997年 / 278卷 / 5342期

关键词：

D O I：

10.1126/science.278.5342.1470

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

CCR5 and CD4 are coreceptors for immunodeficiency virus entry into target cells, The gp120 envelope glycoprotein from human immunodeficiency virus strain HIV-1(YU2) bound human CCR5 (CCR5(hu)) or rhesus macaque CCR5 (CCR5(rh)) only in the presence of CD4. The gp120 from simian immunodeficiency virus strain SIVmac239 bound CCR5(rh) without CD4, but CCR5(hu) remained CD4-dependent. The CD4-independent binding of SIVmac239 gp120 depended on a single amino acid, Asp(13), in the CCR5(rh) amino-terminus. Thus, CCR5-binding moieties on the immunodeficiency virus envelope glycoprotein can be generated by interaction with CD4 or by direct interaction with the CCR5 amino-terminus. These results may have implications for the evolution of receptor use among lentiviruses as well as utility in the development of effective intervention.

引用

页码：1470 / 1473

页数：4

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