Analysis of exhaled breath condensate for monitoring airway inflammation

被引：138

作者：

Montuschi, P ^{[1
]}

Barnes, PJ

机构：

[1] Univ Cattolica Sacro Cuore, Dept Pharmacol, Sch Med, I-00168 Rome, Italy

[2] Univ London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, Dept Thorac Med, Sch Med, London SW3 6LY, England

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 2002年 / 23卷 / 05期

关键词：

D O I：

10.1016/S0165-6147(02)02020-5

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Several inflammatory mediators have been identified in the exhaled breath condensate (E:BC) that is formed by breathing through a cooling system. Analysis of EBC is a noninvasive method that allows repeat measurements of lung inflammation and is potentially useful for monitoring drug therapy. Characterization of the profiles of exhaled markers could help to discriminate between different inflammatory lung diseases; thus, EBC might be a novel, noninvasive approach to monitoring lung diseases. However, several methodological issues, such as standardization of sample collection and validation of analytical techniques, need to be addressed before this method can be applied clinically. Controlled studies are needed to establish the utility of EBC markers for guiding pharmacological treatment in inflammatory lung diseases.

引用

页码：232 / 237

页数：6

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