Cytokine receptor signal transduction and the control of hematopoietic cell development

被引：153

作者：

Watowich, SS

Wu, H

Socolovsky, M

Klingmuller, U

Constantinescu, SN

Lodish, HF

机构：

[1] WHITEHEAD INST BIOMED RES, CAMBRIDGE, MA 02142 USA

[2] MIT, DEPT BIOL, CAMBRIDGE, MA 02139 USA

来源：

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY | 1996年 / 12卷

关键词：

cytokine receptors; hematopoiesis; signal transduction; receptor-associated diseases;

D O I：

10.1146/annurev.cellbio.12.1.91

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The cytokine receptor superfamily is characterized by structural motifs in the exoplasmic domain and by the absence of catalytic activity in the cytosolic segment. Activated by ligand-triggered multimerization, these receptors in turn activate a number of cytosolic signal transduction proteins, including protein tyrosine kinases and phosphatases, and affect an array of cellular functions that include proliferation and differentiation. Molecular study of these receptors is revealing the roles they play in the control of normal hematopoiesis and in the development of disease.

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收藏

页码：91 / 128

页数：38

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