Oligodendroglial-specific transcriptional factor SOX10 is ubiquitously expressed in human gliomas

被引:53
作者
Bannykh, SI
Stolt, CC
Kim, J
Perry, A
Wegner, M
机构
[1] Yale Univ, Sch Med, Dept Pathol, New Haven, CT 06521 USA
[2] Univ Erlangen Nurnberg, Inst Biochem, Erlangen, Germany
[3] Washington Univ, Sch Med, Div Neuropathol, St Louis, MO USA
关键词
astrocytoma; expression; oligodendroglioma; pathogenesis; pilocytic astrocytoma; SOX10;
D O I
10.1007/s11060-005-5533-x
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The two most common types of gliomas: astrocytoma and oligodendroglioma are distinguished based on their morphologic similarities to mature astrocytes and oligodendroglia. Whereas prototypical examples of the tumors have distinct pathogenetic and prognostic differences, the majority of the gliomas falls in the intermediate category and their distinction is problematic. The transcriptional factor SOX10 is one of the key determinants of oligodendroglial differentiation. We applied immunohistochemistry to analyze whether the expression of SOX10 can differentiate astrocytoma and oligodendroglioma. The majority of oligodendrogliomas, but also a large fraction of astrocytomas, including the least differentiated glioblastomas, expressed SOX10, albeit at lower levels. Comparison with 1p and 19q deletion status by FISH analysis also revealed no obvious associations. High levels of expression were also found in pilocytic astrocytoma, consistent with recent studies suggesting that pilocytic astrocytomas have greater overlap with oligodendroglial than astrocytic tumors. Our data raise a possibility that histogenesis of gliomas have more common features than previously anticipated.
引用
收藏
页码:115 / 127
页数:13
相关论文
共 75 条
[1]   Analysis of the bHLH transcription factors Olig1 and Olig2 in brain tumors [J].
Aguirre-Cruz, L ;
Mokhtari, K ;
Hoang-Xuan, K ;
Marie, Y ;
Criniere, E ;
Taillibert, S ;
Lopes, M ;
Delattre, JY ;
Sanson, M .
JOURNAL OF NEURO-ONCOLOGY, 2004, 67 (03) :265-271
[2]   bHLH transcription factor Olig1 is required to repair demyelinated lesions in the CNS [J].
Arnett, HA ;
Fancy, SPJ ;
Alberta, JA ;
Zhao, C ;
Plant, SR ;
Kaing, S ;
Raine, CS ;
Rowitch, DH ;
Franklin, RJM ;
Stiles, CD .
SCIENCE, 2004, 306 (5704) :2111-2115
[3]   Immunolocalization of the oligodendrocyte transcription factor 1 (Olig1) in brain tumors [J].
Azzarelli, B ;
Miravalle, L ;
Vidal, R .
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 2004, 63 (02) :170-179
[4]  
Bailey P., 1927, CLASSIFICATION TUMOR, V14, P554, DOI DOI 10.1002/BJS.1800145540
[5]  
BELLO MJ, 1995, INT J CANCER, V64, P207
[6]   MOLECULAR ANALYSIS OF CHROMOSOME-1 ABNORMALITIES IN HUMAN GLIOMAS REVEALS FREQUENT LOSS OF 1P IN OLIGODENDROGLIAL TUMORS [J].
BELLO, MJ ;
VAQUERO, J ;
DECAMPOS, JM ;
KUSAK, ME ;
SARASA, JL ;
SAEZCASTRESANA, J ;
PESTANA, A ;
REY, JA .
INTERNATIONAL JOURNAL OF CANCER, 1994, 57 (02) :172-175
[7]   Human Connexin 32, a gap junction protein altered in the X-linked form of Charcot-Marie-Tooth disease, is directly regulated by the transcription factor SOX10 [J].
Bondurand, N ;
Girard, M ;
Pingault, V ;
Lemort, N ;
Dubourg, O ;
Goossens, M .
HUMAN MOLECULAR GENETICS, 2001, 10 (24) :2783-2795
[8]   Shared oligodendrocyte lineage gene expression in gliomas and oligodendrocyte progenitor cells [J].
Bouvier, C ;
Bartoli, C ;
Aguirre-Cruz, L ;
Virard, I ;
Colin, C ;
Fernandez, C ;
Gouvernet, J ;
Figarella-Branger, D .
JOURNAL OF NEUROSURGERY, 2003, 99 (02) :344-350
[9]   The transcription factor Sox10 is a key regulator of peripheral glial development [J].
Britsch, S ;
Goerich, DE ;
Riethmacher, D ;
Peirano, RI ;
Rossner, M ;
Nave, KA ;
Birchmeier, C ;
Wegner, M .
GENES & DEVELOPMENT, 2001, 15 (01) :66-78
[10]  
Burger P, 2002, SURG PATHOLOGY NERVO, P657