Platelet size has diagnostic predictive value in patients with thrombocytopenia

被引：96

作者：

Bowles, KM ^{[1
]}

Cooke, LJ ^{[1
]}

Richards, EM ^{[1
]}

Baglin, TP ^{[1
]}

机构：

[1] Addenbrookes NHS Trust, Dept Haematol, Cambridge CB2 2QQ, England

来源：

CLINICAL AND LABORATORY HAEMATOLOGY | 2005年 / 27卷 / 06期

关键词：

thrombocytopenia; diagnostic haematology; mean platelet volume; bone marrow pathology;

D O I：

10.1111/j.1365-2257.2005.00726.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We studied 473 unselected patients with thrombocytopenia. The mean platelet volume (MPV) was 8.1 fl in patients with marrow disease and 9.8 fl in patients without marrow disease (P < 0.001). A total of 5% of patients with an MPV >= 10.5 fl have marrow disease (odds ratio 0.05, 95% CI 0.02-0.13). Conversely over three quarters of patients with an MPV of < 8.0 fl have marrow disease (odds ratio 8.1, 95% CI 5.0-13.0). Therefore the MPV can strongly guide the clinician as to the likely presence or absence of bone marrow disease in thrombocytopenic patients.

引用

页码：370 / 373

页数：4

共 7 条

[1]

GILES C, 1981, BRIT J HAEMATOL, V48, P31

[2] Emergency room triage of patients with acute chest pain by means of rapid testing for cardiac troponin T or troponin I [J].

Hamm, CW ;

Goldmann, BU ;

Heeschen, C ;

Kreymann, G ;

Berger, J ;

Meinertz, T .

NEW ENGLAND JOURNAL OF MEDICINE, 1997, 337 (23) :1648-1653

[3] Platelet size deviation width, platelet large cell ratio, and mean platelet volume have sufficient sensitivity and specificity in the diagnosis of immune thrombocytopenia [J].

Kaito, K ;

Otsubo, H ;

Usui, N ;

Yoshida, M ;

Tanno, J ;

Kurihara, E ;

Matsumoto, K ;

Hirata, R ;

Domitsu, K ;

Kobayashi, M .

BRITISH JOURNAL OF HAEMATOLOGY, 2005, 128 (05) :698-702

[4]

REARDON DM, 1991, MED LAB SCI, V48, P19

[5] THE ROUTINE MEASUREMENT OF PLATELET VOLUME - A COMPARISON OF APERTURE-IMPEDANCE AND FLOW CYTOMETRIC SYSTEMS [J].

REARDON, DM ;

HUTCHINSON, D ;

PRESTON, FE ;

TROWBRIDGE, EA .

CLINICAL AND LABORATORY HAEMATOLOGY, 1985, 7 (03) :251-257

[6] THE ROUTINE MEASUREMENT OF PLATELET VOLUME - A COMPARISON OF LIGHT-SCATTERING AND APERTURE-IMPEDANCE TECHNOLOGIES [J].

TROWBRIDGE, EA ;

REARDON, DM ;

HUTCHINSON, D ;

PICKERING, C .

CLINICAL PHYSICS AND PHYSIOLOGICAL MEASUREMENT, 1985, 6 (03) :221-238

[7] Evaluation of D-dimer in the diagnosis of suspected deep-vein thrombosis [J].

Wells, PS ;

Anderson, DR ;

Rodger, M ;

Forgie, M ;

Kearon, C ;

Dreyer, J ;

Kovacs, G ;

Mitchell, M ;

Lewandowski, B ;

Kovacs, MJ .

NEW ENGLAND JOURNAL OF MEDICINE, 2003, 349 (13) :1227-1235

← 1 →