Molecular biology of pancreatic cancer

被引：10

作者：

Belda-Iniesta, Cristobal ^{[1
,2
]}

Ibanez de Caceres, Inmaculada ^{[3
]}

Barriuso, Jorge ^{[1
]}

de Castro Carpeno, Javier ^{[1
]}

Gonzalez Baron, Manuel ^{[1
,2
]}

Feliu, Jaime ^{[1
]}

机构：

[1] Univ Autonoma Madrid, Univ Hosp La Paz, Div Med Oncol, CSIC,Translat Oncol Unit, ES-28046 Madrid, Spain

[2] MD Anderson Canc Ctr Espana, Madrid, Spain

[3] Univ Autonoma Madrid, CSIC, Biomed Res Inst Alberto Sols, Translat Oncol Unit, ES-28046 Madrid, Spain

来源：

CLINICAL & TRANSLATIONAL ONCOLOGY | 2008年 / 10卷 / 09期

关键词：

pancreatic cancer; K-ras; cyclins; TGF beta; STAT3; EGFr;

D O I：

10.1007/s12094-008-0247-6

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Pancreatic cancer is a leading cause of cancer death. This devastating disease has the horrible honour of close to equal incidence and mortality rates. Late diagnosis and a constitutive resistance to every chemotherapy approach are responsible for this scenario. However, molecular biology tools in cooperation with translational efforts have dissected several secrets that underlie pancreatic cancer. Progressive acquisition of malignant, invasive phenotypes from pre-malignant lesions, recent revelations on core signalling pathways and new targeted designed trials offer a better future for pancreatic cancer patients. This review will summarise recent advances in the molecular biology of pancreatic cancer.

引用

收藏

页码：530 / 537

页数：8

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