Protein recognition by cell surface receptors: physiological receptors versus virus interactions

被引：61

作者：

Wang, JH

机构：

[1] Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Pediat, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Dept Biol CheM & Mol Pharmacol, Boston, MA 02115 USA

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2002年 / 27卷 / 03期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0968-0004(01)02038-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Protein-protein recognition is a major kind of receptor-ligand interaction: a living cell receives external signals to adapt to the environment through cell surface receptors. On opposing cell surfaces, such recognition bears distinct features: it is a multivalent, reversible and avidity-driven process. The affinity between each individual contacting pair is low. Viruses might take advantage of this low affinity to invade a host cell by evolving a stronger binding affinity to the surface receptors than that associated with physiological ligands. Structural data appear to support this notion.

引用

收藏

页码：122 / 126

页数：5

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